Chief Science Officer (NCI) - Frederick, MD | Biospace
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Chief Science Officer (NCI)

Leidos Biomedical Research, Inc.

Frederick, MD
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Areas of Expertise Desired:

Job Description

Leidos Biomedical Research, Inc. (LBRI), a wholly owned subsidiary of Leidos, operates the Frederick National Laboratory for Cancer Research (FNLCR). FNLCR is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI). It is the only FFRDC dedicated to biomedical research. Through its status as an FFRDC, FNLCR provides NCI and others with a unique national resource to accelerate the development and delivery of effective preventive, diagnostic, and therapeutic products for cancer and AIDS.

The breadth of FNLCR’s activities spans the research and development spectrum, including investigator-initiated, hypothesis-driven research into cancer and AIDS; advanced technology programs focused on genetics and genomics, proteins and proteomics, imaging, nanotechnology, bioinformatics, and laboratory animal sciences; clinical operations in support of NCI and National Institute of Allergy and Infectious Diseases (NIAID)-sponsored clinical trials, as well as NCI drug discovery and development efforts; and management and operations of biopharmaceutical development and manufacturing programs under current Good Manufacturing Practice conditions for NCI and NIAID. Administrative, procurement, financial, safety, and facilities support is provided to these R&D activities using state-of-the-art business processes.  LBRI has approximately 1,900 employees and manages an annual operating budget exceeding $500M.

For more information about Leidos Biomedical Research Inc., please visit our webpage at

The Chief Science Officer leads the Science and Technology Group (STG) and is responsible for the following programs in support of the FNLCR mission:

AIDS and Cancer Virus Program (ACVP): operates an integrated, multidisciplinary program that pursues basic and applied studies aimed at improving the understanding of AIDS-associated viruses, including studies intended to facilitate the improved diagnosis, prevention and treatment of HIV infection and AIDS, and AIDS related tumors, particularly those associated with other viruses such as KSHV. The Program consists of five independent but highly interactive research sections headed by Principal Investigators, whose work spans from fundamental molecular virology through in vitro studies, to in vivo studies in non-human primate (NHP) models, to international viral epidemiology.  The ACVP also has multiple Research Support Core Groups (Cores) that provide critical and often unique technical support capabilities to ACVP laboratories and other laboratories within the NCI, NIH, and to extramural investigators.

Basic Science Program (BSP): operates in support of NCI’s Center for Cancer Research (CCR) investigator-initiated, hypothesis-driven multidisciplinary research programs in basic or applied molecular biology, immunology, retrovirology, cancer biology, and human genetics. BSP also provides a variety of research and administrative support capabilities that complement CCR research efforts.  

Cancer Research Technology Program (CRTP): develops and implements emerging technologies, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover or develop new therapeutic interventions against RAS-driven cancers. In addition, the CRTP also hosts the Nanotechnology Characterization Laboratory (NCL) which develops and conducts standardizes assays of preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists work collaboratively with intramural NCI investigators to provide research technologies and expertise.

Information Systems Program: provides information systems in support of FNLCR and NCI research and development efforts.  The program is composed of five functional areas: 1) the Advanced Biomedical Computing Center (ABCC) provides scientific and bioinformatics support, 2) the Center for Bioinformatics and Information (CBIIT) Technical Support Group (CTSG) provides integrated program management, operational, development, and analysis support, 3) the IT Operations Group (ITOG) serves as the primary provider and maintainer of the cyberinfrastructure for FNLCR and NCI, 4) the Information Security and Compliance Office (ISCO) oversees data and network security and privacy for FNLCR and its subcontractors’ IT systems connected to the NCI network,  and 5) the Program Administration Office (PAO) oversees ISP business operations.

Laboratory Animal Science Program (LASP): provides AAALAC accredited animal-based research and support services to investigators located at the FNLCR and to NCI investigators located at the NIH campus in Bethesda, Maryland.
Programs provided by LASP include:  Animal Care and Technical Support, Pathology/Histotechnology, Animal Health Diagnostics, Transgenic/Knockout Services, Speed Congenics, Cryopreservation/Breeding, Mouse Model Repositories, Small Animal Imaging, and Veterinary Support.  

The Chief Science Officer (CSO) reports to the FNLCR Laboratory Director.

The Chief Science Officer (CSO) will identify new scientific and technological opportunities which facilitate achievement of the mission of the FNLCR and will lead efforts to build research and technology partnerships with academia, Government, and private-sector partners. As a member of the LBRI leadership team, the CSO will contribute to the overall strategic direction of the FNLCR, by providing guidance with respect to research direction and portfolio prioritization, operating and capital budget allocation, and workforce management decisions. The incumbent will:
Direct the STG management staff in bringing performance improvement by identifying, developing, and implementing innovation, contemporary best-practices, and the application of solutions that increase employee productivity and customer satisfaction.
Provide expertise in the development and application of state-of-the-art advanced technologies, especially in the context of drug discovery and the translation of research to a clinical setting.
Maintain technical currency and apply this knowledge to evaluate new and emerging technologies for potential transfer into or from LBRI.
Collaborate with NCI for strategic scientific planning initiatives.
Provide senior leadership to support the Cancer Research Technology Program and comparable collaborations between NCI, FNLCR and other organizations.
Oversee the establishment and management of programs in support of new Government efforts at FNLCR.
Hire, train, develop, and manage staff to ensure that it maintains currency in its knowledge of and experience with relevant information technology systems and tools.
Direct planning and policy development activities and ensure compliance with all contractual requirements.
Interface with Federal, Corporate, and other authorized organizations for audit and compliance purposes.
Develop and sustain effective relationships with Federal and FNLCR contractor customers, business and research partners, and the NCI’s on-site FNLCR staff.
Serve as a member of the LBRI Leadership Team.  Provide input to enhance FNLCR’s enterprise-wide performance improvement.


Ph.D. from an accredited university according to the Council for Higher Education Accreditation (CHEA) in a relevant field or MD with extensive research experience preferred.
Education or research emphasis must include a focus on cancer biology.
Foreign degrees must be evaluated for U.S. equivalency.
Significant record of publication in peer-reviewed journals
A minimum of ten (10) years of progressively responsible relevant experience, including experience at the senior leadership level
Strong scientific management and technical expertise related to all applicable functional areas
Demonstrated understanding of advanced biomedical technologies, such as next generation sequencing, proteomics, informatics, imaging, and nanotechnology, and their application
Application of leadership and management principles in large, complex organizations
Ability to manage complex operations and teams; ability to apply effective leadership and interpersonal skills through use of strategic thinking, team and project leadership, personnel development and decision-making skills
National laboratory experience
Experience working in a federal contracting environment