Cell Therapy Development Scientist/Senior Scientist - South San Francisco, CA | Biospace
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Cell Therapy Development Scientist/Senior Scientist

Nkarta Inc

Location:
South San Francisco, CA
Posted Date:
8/4/2017
Position Type:
Full time
Job Code:
Salary:
Required Education:
Doctorate/PhD
Areas of Expertise Desired:

Job Description

Nkarta Therapeutics, Inc.is a private biotech start-up that is harnessing the power of Natural Killer cells in developing next generation cellular immunotherapies for cancer. NK cells play a key role in the body’s immune system, able to identify and kill abnormal cells by monitoring their expression of activating and inhibitory receptors and recruit the adaptive immune system.  
Nkarta will combine its NK expansion platform with further proprietary cell engineering technologies to build differentiated products designed to tackle challenging diseases with significant unmet clinical need.
Nkarta is currently offering a unique opportunity for a highly-motivated Scientist or Senior Scientist to join our team with expertise in process development for cell therapy.  Initial responsibilities will include translating bench methods, and protocols into robust processes for the manufacture of advanced NK cell therapies.  The qualified candidate will coordinate closely with internal and external partners in a cross-disciplinary team of immunologists, engineers, and clinicians to develop and implement protocols that embody best practices in biologics manufacturing.
Responsibilities:
•   Development of phase-appropriate cell therapy production processes using quality-by-design principles
•   Assist in tech transfer to internal partners and CMOs for GMP manufacturing including risk assessment and mitigation strategy development
•   Process optimization to create manufacturing efficiency, process robustness and reduced costs
•   Identify and support the development of critical product-specific analytical methods for the characterization and release of cell therapy products
•   Demonstrate a high level of initiative in troubleshooting experiments and accurate data analysis.
•   Participating in cross-functional collaborations to meet project timelines and material supply requirements
•   Support investigational new drug (IND) chemistry-manufacturing-control (CMC) section writing
•   Provide management guidance through presentation of hypotheses, progress, and plans to project teams and governance bodies and preparation of technical reports
•   Publishing or presenting scientific findings in peer-reviewed journals or conferences, and contributing to industrial collaborations

Requirements

Requirements
•   Ph.D. degree in Bioengineering, Biomedical Engineering, Process Engineering, or related field with 6-8 years of post-graduate experience preferred (may include post-doctoral experience).
•   Previous exposure to GMP manufacturing of cell therapy or biological products is strongly preferred.  The ideal candidate will have participated in technical transfer of clinical processes to a CMO or other third party
•   Experience developing cell therapy production processes and an understanding of viral transduction principles and processes is a plus
•   Thorough understanding of Design of Experiment (DOE) and Quality by Design (QBD)
•   Excellent communication skills, both written and oral, and high degree of organization in terms of goal setting and achieving
•   The ideal candidate will have at least 2-4 years of biopharmaceutical industry experience in a development setting
•   Experience in managing and leading small teams within proscribed timelines and budgets
•   Independence and creative problem-solving abilities; comfort working in the fluid structure of start-up biotech.  Integrity, confidence, and passion will be highly valued
•   Willingness to travel

Nkarta offers a creative, team-oriented scientific environment, along with a strong compensation package that includes salary, stock options, and a comprehensive benefits package.