Biologist-Protein Optimization Group-FDE - Indianapolis, IN | Biospace
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Biologist-Protein Optimization Group-FDE

Eli Lilly and Company

Indianapolis, IN
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Bachelors Degree
Areas of Expertise Desired:
Biology, Immunology, Protein,

Job Description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

We are the Protein Optimization Team of Biotechnology Discovery Research responsible for generating, characterizing, and optimizing biotherapeutics from lead generation to lead optimization and preclinical development. We are seeking a motivated research associate to join our talented multidisciplinary team.  You will be responsible for generating data to provide a deeper understanding of Fc-receptor biology. You will also be responsible for in vitro characterization of immune cell-mediated effector function potential of therapeutic antibodies or Fc fusion proteins, executing new technologies, protocols and assay techniques for assessing effector function response in humans, mouse and non-human primates.  Experience in the use and design of cell-based reporter assays is important. You should also possess strong core competency in immunology, with experience in molecular and immunological techniques such as primary cell isolation, immune cell functional assays, ELISA/Luminex/MSD, mammalian cell tissue culture, western blots, flow cytometry and/or RT-qPCR.  Experience with molecular biology techniques, and microscopy is preferred. Moreover, as part of the Protein Optimization Team you will engage in cross-disciplinary efforts across discovery and development.

Some key responsibilities within this role are:
1.In vitro characterization of Fc-mediated effector function response. Isolation and maintenance of primary cells from blood samples or animal tissues as well as stable/overexpression cell lines for cell-based reporter assays.
2.Characterize target cell phenotype as well as dissect Fc-receptor signaling pathways using techniques such as western blots, flow cytometry, RT-qPCR and or ELISA/Luminex/MSD.
3.Work in multifunctional teams.
4.Present experimental data at team meetings

*Travel Percentage  

Additional Information  
This position is not permanent. It is for a fixed duration of two years with potential to extend annually for up to 4 years.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Lilly credits its exceptional employees for its successes, and knows the key to ongoing achievement lies in attracting and retaining the best people. A company rich in heritage, Lilly employs individuals, conducts research and markets products worldwide. By providing for the unmet needs of our customers through a continuous stream of innovation, we will outgrow all competitors.

Lilly earns consistent and wide recognition for creating an exceptional work environment:
•Business Week magazine 50 Best Places To Launch A Career™
•FORTUNE America’s Most Admired Companies™
•FORTUNE 50 Best Companies for Minorities™
•Working Mother 100 Best Companies for Working Mothers™
•Industry Week magazine 100 Best-Managed Companies™
•Science magazine Best Companies for Scientists™


*Basic Qualifications  
•Bachelor Degree in Biological Science or related field with at least 2 years of research experience or
•MS degree in Biological Sciences, Immunology or related field is required.
•Qualified candidates must be legally authorized to be employed in the United States. Lilly does not anticipate providing sponsorship for employment visa status (e.g., H-1B or TN status) for this employment position.

Additional Skills/Preferences  
•Capability of independently designing experiments, generating data, interpreting results and documenting work.
•Effective oral and written communication skills, self management, task planning and organization skills.
•Pharmaceutical experience is preferred.
•Demonstrated ability to work in a team environment