Biochemistry/Enzymology Research Associate: Oncology Biological Chem - Cambridge, MA | Biospace
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Biochemistry/Enzymology Research Associate: Oncology Biological Chem

Novartis Oncology

Cambridge, MA
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Bachelors Degree
Areas of Expertise Desired:

Job Description

The Biological Chemistry group is an early stage drug discovery team within Oncology research at NIBR, focused on understanding and exploiting the molecular mechanisms of novel cancer targets for the discovery, characterization and optimization of small molecule therapeutics. We are seeking a highly motivated, creative and collaborative scientist to join our team in a hands-on role to discover the next generation of innovative cancer treatments.

Responsibilities for the role include:

-   Functional and mechanistic characterization of enzymes, substrates, multi-protein complexes

-   Design, development and troubleshooting of diverse biochemical and biophysical assays for use in the assessment of both mechanism and small molecule modulation of cancer targets, including hit identification, validation and optimization

-   Analysis, interpretation, documentation and presentation of data to local groups and project teams

-   Assessment of emerging technologies with an emphasis towards the adoption and implementation of new experimental techniques enabling drug discovery

-   Contribution to group knowledge and expertise through collaboration and idea exchange with multidisciplinary teams

EEO Statement   The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.


-   BA/BS or MS degree in Biochemistry, Biophysics, Enzymology or a related field with 5+ years of relevant industry experience

-   A solid understanding of protein function and enzyme mechanism; experience with biochemical and biophysical assay development for protein target and small molecule inhibitor characterizations as well as protein-ligand binding interactions

-   Experience with fluorescence-based assay techniques (e.g. HTRF, FP, quench assays) and label-free technologies (e.g. SPR, ITC, DSC, LC-MS) is desired

-   Protein expression and purification skills as well as protein analytical skills (e.g. gel electrophoresis, Western blotting, and size exclusion chromatography) are desired

-   Interest in implementing innovative assay technologies, and developing novel assay approaches to support drug discovery programs

-   Demonstrated ability to analyze, interpret and present data in a clear manner

-   An interest in contributing to medicinal chemistry drug discovery efforts to evaluate compound SAR and mode of action characterization

-   Excellent communication and inter-personal skills

At NIBR we believe that along with our scientists, our culture is our greatest asset. To drive that culture each employee is expected to function in an innovative and collaborative manner. Each successful candidate will be able to demonstrate how they have functioned in this manner to drive results.