Associate Scientist I, Mass Spectrometry - Foster City, CA | Biospace
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Associate Scientist I, Mass Spectrometry

Gilead Sciences, Inc.

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Location:
Foster City, CA
Posted Date:
8/9/2017
Position Type:
Full time
Job Code:
R0000839
Salary:
Required Education:
Bachelors Degree
Areas of Expertise Desired:
Mass Spectrometry, Scientist,

Job Description

Major responsibilities include, but are not limited, to the following:
•   Experience in the preparation of samples for LC-MS analysis including proteolytic digestion, solid phase extraction, enrichment and fractionation.
•   Assists with intact protein mass analysis, peptide mapping, LC MS/MS analysis for target ID.
•   Operate, maintain and troubleshoot liquid chromatography, mass spectrometers and auxiliary instrumentation.
•   Effectively design and implement new SOPs. Acquire and maintain current knowledge of proteomic sample preparation by reading the literature, and attending meetings and conferences.
•   Maintain records on location of research samples; schedule work flow for most efficient use of instrument time.
•   Employ scientific background and communication skills to professionally support investigators by recommending sample preparation methods, advising in experimental design, and assisting in the analysis, evaluation, and interpretation of experimental results.
•   Participates in the development of mass spectrometry-related methods for process science and research programs
•   Participate in the preparation of written documents, including procedures, presentations, and proposals, in conjunction with other staff.

Requirements

Knowledge, Experience and Skills          
•   Strong hands on instrumentation skills for evaluation and implementation of cutting edge mass spectrometry applications.
•   Hands on experience operating and analyzing data from Agilent TOF, qTOF, QQQ mass spectrometer(s) is highly desirable. Knowledge of other mass spectrometry platforms including Thermo is a plus.
•   Experience with mass spectrometry of proteins and peptides, including peptide quant, antibody characterization, glycan analysis, intact protein characterization, proteomics, phospho-proteomics, differential analysis, and automation platforms desired.
•   Experience with skyline and peaks among other software packages preferred.
•   Understanding of co-immunoprecipitation, cellular fractionation and biofluid processing methods a plus
•   Previous experience with bottom-up proteomic workflows and data analysis a plus.
•   Must be able to quickly assimilate and apply new knowledge and concepts.
•   Be comfortable and independent spending a majority of time doing bench-top science.
•   Ability to multi-task in an extremely dynamic environment while providing high-quality analytical support in a professional, pleasant, and tactful manner is a necessity.
•   Strong communication & interpersonal skills are essential for success in this collaborative role.
•   Minimum relevant industrial experience:  B.S., 9+  yrs, M.S., 8+  yrs, or PhD. 0-3 years.  Job title will be commensurate with experience.

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