Associate Scientist I/II, Bioprocess Engineering - Gaithersburg, MD | Biospace
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Associate Scientist I/II, Bioprocess Engineering

MedImmune, LLC

Gaithersburg, MD
Posted Date:
Position Type:
Full time
Job Code:
Required Education:
Masters Degree
Areas of Expertise Desired:

Job Description

Gaithersburg, Maryland, United States
Job reference: R-007865
Posted date: Sep. 01, 2017

If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us.

MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  As a Research Associate II in Gaithersburg, MD, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.

We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Main Duties and Responsibilities

This position fulfills a critical role within BioProcess Engineering for providing technical support and implementing process improvements at the Development Scale-up Center. The BioProcess Engineering department (within Research & Development) is responsible for production of materials for toxicology studies, process scale up, and transfer of processes to clinical and commercial manufacturing. Members of the Development Scale-up Center (DSC) produce material for toxicology studies, execute process development studies, prepare technical summary reports and evaluate new purification technologies.

Specific responsibilities for this position include:

This is a hands-on, laboratory role working with a team of scientists and engineers to perform scale-up batches of a development process prior to introduction into GMP facilities. As part of batch execution, the ASI will prepare large volume buffers, pack chromatography columns, program and operate chromatography skids and filtration equipment.  Additionally the ASI will meet regularly with purification scientists and engineers to review process data and results. Other key responsibilities include identifying root causes for deviations, recommending process changes for improved robustness and/or scalability, evaluating and implementing innovative and/or replacement technologies and analyzing performance data to identify potential areas for improvement.  The ASI will be expected to prepare run summary reports, technical presentations for internal and external departments and collaborate with vendors to evaluate new technologies.  The ASI will work both independently and as part of a team on a variety of projects.

This position reports to the SUL/DSC Downstream manager and does not have any direct reports.


Essential Requirements

  • Bachelor’s degree in Biochemistry, Chemical Engineering or related with 5-10  years of experience, or a Master’s degree and 2-7 years of combined industry experience related to process development, manufacturing or related field is preferred. I
  • In addition, the individual is expected to possess strong technical skills and experience with biopharmaceutical operations and equipment. Requires knowledge of biologics purification such as chromatography, virus filtration, ultrafiltration and diafiltration.
  • Good interpersonal skills and ability to interact with team members and cross-functional teams is required.
  • Must have the ability to independently coordinate and prioritize multiple projects in a fast-paced environment, as well as the ability to work independently and within a team setting.
  • Familiarity with root cause analysis and problem-solving tools is a plus.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.