If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us.
MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease. As an Associate Scientist I/II in Gaithersburg, MD, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.
We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.
MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.
We have an opening for an Associate Scientist II/Associate Scientist I in the Antibody Discovery and Protein Engineering department within the Research organization to conduct pre-clinical research and technology development in the area of bispecific antibodies and other biological entities. The Associate Scientist II/Associate Scientist I will be responsible for molecular cloning, recombinant protein expression, early stability assessment, analytical and functional characterization of bispecific antibodies and other biological entities.He/she will need to collaborate with biologists, toxicologists, pharmacologists and process scientists to ensure the delivery of bispecific molecules and other biologics meet desired biological, biophysical and manufacturability properties
Main Duties and Responsibilities
Independently conduct laboratory experiments that include cloning, protein expression in mammalian cells, protein purification, biochemical and biophysical studies (i.e. affinity purification; size-exclusion chromatography; reverse phase chromatography; hydrophobic interaction chromatography; spectroscopy; mass spectrometry), binding studies (i.e. ELISA, FACS, BIAcore). It is expected that he/she will be able to troubleshoot problems and assist senior scientists with design and execution of experiments. He/she is expected to present updates to research and development project teams. He/she must maintain accurate and timely laboratory notebooks and other data records.
Bachelor of Science in Molecular Biology, Biochemistry, or related field with a minimum of two years (Associate Scientist I) or five years (Associate Scientist II) of experience in the bio-pharmaceutical industry. Hands on laboratory experience in molecular biology, protein chemistry, antibody or protein engineering.
Proven knowledge with cloning and various analytical methodologies such as affinity purification; size-exclusion chromatography; reverse phase chromatography; hydrophobic interaction chromatography; spectroscopy; mass spectrometry), binding studies (i.e. ELISA, FACS, BIAcore). Ability to provide critical interpretation of results. Ability to multitask and handle multiple priorities in a fast-paced environment. Excellent written and verbal communications skills. Problem-solving skills and independent research experience as demonstrated by publication records (i.e. PubMed, investigator reports). Ability to work in cross-functional teams. Great teamwork and communication skills, both verbal and written, are critical.
Documented experience with working with bispecific antibodies. Relevant experience in biotech or pharmaceutical companies.
This is a full-time laboratory position. Candidates with a recently obtained PhD (i.e. less than one year) in antibody engineering or related disciplines are encouraged to apply.
Next Steps – Apply today!
To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.