To underpin our commitment to bring safe and transformative medicines to patients, we are growing our highly innovative Translational Systems Toxicology group at Amgen. Our mission is to ensure that both the drugs and drug targets we develop are safe and that side effects are minimized or eliminated. To achieve this we are applying a variety of human in vitro approaches (including human genetics along with cell, molecular and structural biology techniques) to develop assays that can predict or elucidate mechanisms leading to drug safety issues. In addition to working broadly to support pipeline projects, we are also developing novel methodologies for assessing the safety of our drug targets in human systems with the long-term goal of being able to focus our future regulatory studies in this area.
We are seeking a talented Associate Scientist with expertise in biochemistry to join our growing group. The successful candidate will play a hands on role in the lab as part of our biochemistry and structural biology team.
1) Drive wet lab biochemistry efforts focused on a) understanding the impact of our drugs on the activity of a variety of proteins, b) developing new biochemical assays for use in drug safety screening and c) characterizing the impact of sequence variants on protein activity
2) Functional and mechanistic characterization of enzymes, substrates and multi-protein complexes
3) Design and troubleshooting of a variety of biochemical and biophysical assays and approaches
4) Interfacing with scientists in medicinal chemistry and protein chemistry groups to develop tagged reagents or novel in vitro systems
5) Analysis, interpretation, meticulous documentation and presentation of data in group and department meetings
6) Assessment of new technologies and approaches that can be applied to further our research goals
Master's degree and 2 years of Scientific experience
Bachelor's degree and 4 years of Scientific experience
1) Master's Degree with 3+ years of scientific experience
2) Demonstrated expertise in a variety of biochemical approaches to understand protein function and enzyme kinetics with a particular focus on characterizing their inhibition or activation by small and large molecules
3) Experience of working with a variety of in vitro systems including three-dimensional organ cultures along with expertise in cellular functional endpoint measures in these systems
4) Experience in the synthesis and utility of tagged small molecule probes for the purification of interacting proteins
5) Proficiency with a variety of other molecular and cellular biology and biomarker techniques including molecular cloning, sequence analysis, ELISA etc.
6) Ability to work independently in experimental design, execution and data analysis
7) Comfort in working in a highly interactive and vibrant environment and a passion for teamwork