Associate Director, Clinical Biomarkers Lead at Vertex - Boston, MA | Biospace
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Associate Director, Clinical Biomarkers Lead at Vertex

Vertex

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Location:
Boston, MA
Posted Date:
5/30/2017
Position Type:
Full time
Job Code:
Salary:
Required Education:
Doctorate/PhD
Areas of Expertise Desired:
Biomarker, Clinical Research, Clinical Trial, Drug Discovery,

Job Description

Vertex is a global biotechnology company that aims to discover, develop and commercialize innovative medicines so people with serious diseases can lead better lives. In addition to our clinical development programs focused on cystic fibrosis, Vertex has more than a dozen ongoing research programs aimed at other serious and life-threatening diseases.

Founded in 1989 in Cambridge, Mass., Vertex today has research and development sites and commercial offices in the United States, Europe, Canada and Australia. For four years in a row, Science magazine has named Vertex one of its Top Employers in the life sciences. For additional information and the latest updates from the Company, please visit www.vrtx.com.

We are seeking a highly motivated scientist to act as a Clinical Biomarker Lead, working in a dynamic, cross- functional environment within the clinical development team to implement biomarker strategies for Vertex clinical assets. This position will report to the Sr. Director of clinical Biomarkers.

Key Responsibilities:
•   Provide input as translational biomarker plans are developed by the Translational Biomarker Lead. Responsible for developing the clinical biomarker strategy and implementing it as projects near the clinic.
•   Collaborate with Clinical Study Teams and clinical colleagues to ensure appropriate inclusion of Clinical Biomarkers in clinical studies, including study design.
•   Align with Research to ensure appropriate interpretation of biomarker readouts.
•   Coordinate with Clinical Pharmacology and Modelling & Simulations to support utilization of quantitative pharmacological approaches during development.
•   Work with Project Management to ensure Companion Diagnostics development in parallel to drug development as appropriate. Serve as a key member of project teams, providing expert input to teams and guiding clinical development of biomarkers through the Development phases.
•   Manage work with CRO and/or collaborate with colleagues from Research to ensure fit-for-purpose validation of clinical biomarker assays complete prior to implementation.
•   Partner with colleagues across the clinical and research organizations to foster an end-to-end view of drug development, always focusing on improving patient care.  As well as, with Translational Biomarker and Clinical Development leads identifying opportunities for biomarker-focused external collaboration and lead collaborations

Requirements

Minimum Qualifications:
•   Demonstrated experience with design, execution and analysis of clinical biomarkers readouts of target engagement, PD response, etc
•   Innovative and have the ability to think creatively with a strong drive for decision making.
•   Effective at building alliances across functions, based on end-to-end drug development thinking and experience.
•   Excellent interpersonal and communication skills, able to drive global collaborations across a matrix organization.
Preferred Qualifications:
•   Preferably a PhD and/or MD with development experience (at least 6+ years post-degree experience in Clinical Biomarkers).
•   Experience in neurology is preferable

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.