Principal Scientist, DMPK - Takeda San Diego

Takeda Pharmaceuticals

Location: San Diego, California-San Diego 92101
Posted on: 8/11/2009 7:39:51 AM
Postion type: Full time
Job Code: 4848083
Required Education:
Salary:

DESCRIPTION
OBJECTIVES:
Serve as DMPK and PK/PD expert to discovery project teams, provide input into research strategies and be involved in collaboration with other Takeda sites in advancing compounds to IND. Provide expertise in area of PK/PD data analysis, interpretation and study design, and to participate in core-level decision-making. This individual will be expected to present, promote and defend their ideas in cross-functional team settings, and influence critical strategic decisions in multiple therapeutic areas

ACCOUNTABILITIES:

* Conducts PK and PK/PD analysis during late stage lead optimization through early pre-clinical development, and collaborates in PK/PD and efficacy study design

* Develops robust PK/PD models to illustrate the relationship between PK, PD, and efficacy in animal efficacy models

* Predicts PK, efficacious dose, and optimal dosing schedule in humans

* Designs, executes, and reports key PK studies to support compound progression from lead optimization to clinical candidate selection

* Collaborates with chemists to address structure-DMPK relationship and improves DMPK properties during lead optimization

* Collaborates with safety assessment group on study design and provides toxicokinetic data analysis and interpretation

* Provides on-going PK/PD training and mentoring to TSD PK scientists and helps apply such knowledge to their respective discovery projects

* Effectively communicates results within and outside the organization in various ways such as presentations and publications

* Influences the course of projects, scientific methods and/or technical company direction; develops and executes innovative methodologies to influence research approaches and efforts; devises complex approaches to apply scientific knowledge to solve problems

* Independently designs complex experimental strategies to discover probable drug targets or candidates that address project goals; acts as a technical and management advisor to others; operates with substantial latitude for action or decision

* Identifies, proposes and develops new solutions to the discovery strategy; contributes to development of company's concepts and principles and achieves objectives in creative and effective ways; develops unique solutions to complex problems where analysis of situations or data requires an in-depth evaluation of multiple factors

* Manages other PhD's and/or Research Associates; typically a combination of direct and indirect reports; provides mentoring to all scientific staff

* Manages more than one project of broad scope and high degree of complexity

* Represents own research and may represent company research to senior leadership or for scientific collaborations or at an international scientific conference recognized in the therapeutic discipline

REQUIREMENTS:
EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:

* Ph.D. or Pharm. D. with emphasis in pharmacokinetics and PK/PD and minimum 8 years of relevant experience, OR

* MS in life science and minimum 14 years of relevant experience, OR

* BS in life science and minimum 17 years of relevant experience

* DMPK Leadership in advancing compounds through discovery into IND-enabling stage

* Proficiency in PK, PK/PD, PK/efficacy modeling using various software such as WinNonlin and NONMEM

* Thorough understanding of the commonly used approaches for human PK prediction, and hands-on experience in application to multiple discovery programs

* Successful experience in predicting human efficacious dose and assisting clinical dosing schedule optimization

* Experience in the therapeutic areas of Oncology, Inflammation or Metabolic Disease

* Demonstrated independent thought/creativity in science and success in coordinating and executing research to further corporate goals

* Demonstrated inter-disciplinary knowledge of drug discovery and ability to use this knowledge to influence project strategy

* Demonstrated ability to successfully direct multiple scientific endeavors simultaneously

* High-level technical skills, with demonstrated application and creativity

* Excellent communication, collaboration and multitasking skills and ability to work in a team setting

* High degree of scientific discretion/intuition

* Conveys ideas in an experimentally detailed yet scientifically concise manner

* Demonstrated proficiency at presentation of original work at conferences

* Competent in authorship of peer-reviewed scientific papers

PHYSICAL DEMANDS:

* Exposure to hazardous/toxic/dangerous chemicals

* Prolonged standing and/or sitting.

TRAVEL REQUIREMENTS:

* May travel to various domestic conferences or client sites, including overnight trips

* Some international travel may be required

* Requires a minimum of 2% travel

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