Director, Toxicology California
8/31/2016 11:04 AM

• Develop and oversee non-clinical safety and toxicology drug development plans for small molecule CNS compounds with estimated costs, timing, and risk assessment/management • Identify and resolve nonclinical study operational issues and maintain project timelines • Develop safety-related issue mitigation or resolution plans and coordinate execution of the experimental plan as required • Intera  ...View Job
Principal Statistician California
8/23/2016 10:09 AM

The Principal Statistician (PS) provides overall statistical leadership, direction, and consulting to the Biostatistics, Statistical Programming, Data Management, Clinical R&D and Regulatory Affairs functions relating to the design, analysis and reporting of clinical trials in support of Phase I-IV clinical development and regulatory submission programs. This highly visible role will actively co  ...View Job
Senior Associate Scientist/Scientist, High-Throughput Purification California
8/8/2016 10:38 AM

The successful Senior Associate Scientist/Scientist candidate will be an accomplished chemist/analytical chemist with state of the art knowledge of modern high throughput purification of chiral and achiral small molecules. The individual will be a motivated, creative, hands-on laboratory scientist with the ability to interact effectively with team members in all areas of drug discovery. The indivi  ...View Job
Manager, Clinical Operations California
7/26/2016 11:51 AM

•Manage the day-to-day activities necessary for the successful completion of clinical programs according to the clinical study protocol, DNS Standard Operating Procedures, ICH Guidelines and GCP. •Oversight of CROs, vendors and contract personnel. •May have some site monitoring or co-monitoring responsibility. •All aspects of designated clinical study operations with accountability for meeting   ...View Job
Associate Director, Regulatory Affairs California
7/26/2016 11:35 AM

Working in a team environment, the Regulatory Associate Director will be responsible for development of regulatory strategy as well as hands-on management of all technical and operational aspects related to the regulatory lifecycle (e.g., from preclinical candidate designation through registration) of assigned DNS products. Strategic Planning • Represent the Regulatory Affairs department on m  ...View Job
Associate Scientist, In Vitro Pharmacology California
7/22/2016 4:48 PM

Candidate is responsible for the design and execution of experiments to measure pharmacodynamic effects of novel small molecules that enhance cognition and to biomarker exploration. A scientific background in learning and memory, neurotransmitter pathways, synaptic plasticity and GPCR biology is desired. The candidate will design and execute in vivo, ex vivo, and in vitro experiments, demonstrate   ...View Job
Senior Associate Scientist/Scientist, Analytical Development California
7/13/2016 8:56 AM

DNS has an opportunity for an experienced candidate to perform analytical activities in support of DNS’ small molecule drug substances (NCEs) and drug products in clinical development. This position will work closely with external contract manufacturing and testing organizations and with internal Process Chemistry and Formulation Development functions. The specific skills and responsibilities incl  ...View Job
Scientist III, In Vitro Pharmacology California
6/21/2016 7:05 AM

The successful candidate will be responsible for leading the In Vitro Pharmacology group. Activities of In Vitro Pharmacology include 1) in vivo/ex vivo rodent receptor occupancy, radioligand characterization; 2) development of in vitro/ex vivo/in vivo target engagement assays relevant for synaptic plasticity/cognition; and 3) development of translatable CNS biomarkers. Responsibilities may also  ...View Job
Manager, Clinical Operations California
6/21/2016 7:01 AM

-Manage the day-to-day activities necessary for the successful completion of clinical programs according to the clinical study protocol, DNS Standard Operating Procedures, ICH Guidelines and GCP. -Oversight of CROs, vendors and contract personnel.- -May have some site monitoring or co-monitoring responsibility Responsibilities include: -All aspects of designated clinical study op  ...View Job
Research Associate/Associate Scientist, SGC California
6/21/2016 6:58 AM

The successful Associate Scientist/Research Associate candidate will be an accomplished chemist/analytical chemist with state of the art knowledge of modern equipment for high throughput analysis, purification and synthesis of small molecules. The individual will coordinate and oversee all aspects of technical support as it is relates to laboratory instrumentation and equipment. Additional respons  ...View Job