Scientist, Structural Biology California
10/13/2016 4:06 PM

DNS is seeking an experienced protein chemist for the structural biology department. The candidate will be responsible for the development and implementation of protein purification processes for macromolecular crystallography studies as well as for biochemical/biophysical assay development and screening. The candidate is also required to have an extensive technical background in state-of-the-art   ...View Job
Research Associate, Structural Biology California
10/7/2016 5:19 PM

DNS is seeking an energetic and highly motivated Research Associate to join the protein production group within the Structural Biology department. The candidate will work as part of a team of scientists to support the recombinant production of proteins in milligram-scale quantities for macromolecular crystallographic studies. Major responsibilities will include protein expression in E-coli, inse  ...View Job
Research Associate/Associate Scientist, Structural Biology California
10/3/2016 11:19 AM

DNS is seeking a motivated Research Associate for the Structural Biology Department. The candidate is required to have a broad technical background and experience in state-of-the-art protein purification and crystallization processes necessary to establish procedures that reproducibly lead to the generation of crystallization-grade protein and crystals suitable for structural studies. Major respon  ...View Job
Director, Toxicology California
8/31/2016 11:04 AM

• Develop and oversee non-clinical safety and toxicology drug development plans for small molecule CNS compounds with estimated costs, timing, and risk assessment/management • Identify and resolve nonclinical study operational issues and maintain project timelines • Develop safety-related issue mitigation or resolution plans and coordinate execution of the experimental plan as required • Intera  ...View Job
Principal Statistician California
8/23/2016 10:09 AM

The Principal Statistician (PS) provides overall statistical leadership, direction, and consulting to the Biostatistics, Statistical Programming, Data Management, Clinical R&D and Regulatory Affairs functions relating to the design, analysis and reporting of clinical trials in support of Phase I-IV clinical development and regulatory submission programs. This highly visible role will actively co  ...View Job
Senior Associate Scientist/Scientist, High-Throughput Purification California
8/8/2016 10:38 AM

The successful Senior Associate Scientist/Scientist candidate will be an accomplished chemist/analytical chemist with state of the art knowledge of modern high throughput purification of chiral and achiral small molecules. The individual will be a motivated, creative, hands-on laboratory scientist with the ability to interact effectively with team members in all areas of drug discovery. The indivi  ...View Job
Associate Director, Regulatory Affairs California
7/26/2016 11:35 AM

Working in a team environment, the Regulatory Associate Director will be responsible for development of regulatory strategy as well as hands-on management of all technical and operational aspects related to the regulatory lifecycle (e.g., from preclinical candidate designation through registration) of assigned DNS products. Strategic Planning • Represent the Regulatory Affairs department on m  ...View Job
Research Associate/Associate Scientist, In Vitro Pharmacology California
7/22/2016 4:48 PM

Candidate is responsible for supporting target engagement assays for the evaluation of novel small molecules that enhance cognition and for biomarker exploration. The successful candidate will have a scientific background in neuroscience and pharmacology. Hands-on experience using both in vitro and in vivo approaches for CNS targets is highly recommended. The candidate will have proven skillset   ...View Job
Senior Associate Scientist/Scientist, Analytical Development California
7/13/2016 8:56 AM

DNS has an opportunity for an experienced candidate to perform analytical activities in support of DNS’ small molecule drug substances (NCEs) and drug products in clinical development. This position will work closely with external contract manufacturing and testing organizations and with internal Process Chemistry and Formulation Development functions. The specific skills and responsibilities incl  ...View Job
Scientist III, In Vitro Pharmacology California
6/21/2016 7:05 AM

The successful candidate will be responsible for leading the In Vitro Pharmacology group. Activities of In Vitro Pharmacology include 1) in vivo/ex vivo rodent receptor occupancy, radioligand characterization; 2) development of in vitro/ex vivo/in vivo target engagement assays relevant for synaptic plasticity/cognition; and 3) development of translatable CNS biomarkers. Responsibilities may also  ...View Job