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Genes Behind Aggressive Endometrial Cancer, Yale University Study  
1/29/2013 7:32:43 AM

In a major breakthrough for uterine serous carcinoma (USC) -- a chemo-resistant, aggressive form of endometrial cancer, Yale researchers have defined the genetic landscape of USC tumors, findings that point to new treatment opportunities. The collaborative team -- which included researchers with expertise in gynecological cancer, genomics, and computational biology -- identified a number of new genes that are frequently mutated in USC. The results of this comprehensive genetic analysis of USC are published in the Jan. 28 Proceedings of the National Academy of Science (PNAS) online early edition. The researchers were supported as part of a collaborative program with Gilead Sciences, Inc.