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The Risk of Stroke after Percutaneous Vertebroplasty for Osteoporosis: A Population-Based Cohort Study
Published: Tuesday, January 31, 2012
Author: Ching-Lan Wu et al.

by Ching-Lan Wu, Jau-Ching Wu, Wen-Cheng Huang, Hung-Ta H. Wu, Hong-Jen Chiou, Laura Liu, Yu-Chun Chen, Tzeng-Ji Chen, Henrich Cheng, Cheng-Yen Chang


To investigate the incidence and risk of stroke after percutaneous vertebroplasty in patients with osteoporosis.


A group of 334 patients with osteoporosis, and who underwent percutaneous vertebroplasty during the study period, was compared to 1,655 age-, sex- and propensity score-matched patients who did not undergo vertebroplasty. All demographic covariates and co-morbidities were deliberately matched between the two groups to avoid selection bias. Every subject was followed-up for up to five years for stroke. Adjustments using a Cox regression model and Kaplan-Meier analyses were conducted.


A total of 1,989 osteoporotic patients were followed up for 3,760.13 person-years. Overall, the incidence rates of any stroke, hemorrhagic stroke and ischemic stroke were 22.6, 4.2 and 19.6 per 1,000 person-years, respectively. Patients who underwent vertebroplasty were not more likely to have any stroke (crude hazard ratio?=?1.13, p?=?0.693), hemorrhagic stroke (HR?=?2.21, p?=?0.170), or ischemic stroke (HR?=?0.96, p?=?0.90). After adjusting for demographics, co-morbidities and medications, the vertebroplasty group had no significant difference with the comparison group in terms of any, hemorrhagic and ischemic strokes (adjusted HR?=?1.22, 3.17, and 0.96, p?=?0.518, 0.055, and 0.91, respectively).


Osteoporotic patients who undergo percutaneous vertebroplasty are not at higher risk of any stroke in the next five years after the procedure.