BioSpace Collaborative

Academic/Biomedical Research
News & Jobs
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

Free Newsletters
My Subscriptions

News by Subject
News by Disease
News by Date
Search News
Post Your News

Job Seeker Login
Most Recent Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Pharm Country
  Bio NC
  Southern Pharm
  BioCanada East
  C2C Services & Suppliers™


Company Profiles

Research Store

Research Events
Post an Event
Real Estate
Business Opportunities

PLoS By Category | Recent PLoS Articles
Infectious Diseases - Microbiology - Public Health and Epidemiology - Anesthesiology and Pain Management - Biochemistry - Biophysics - Biotechnology - Cardiovascular Disorders - Chemical Biology - Chemistry - Computer Science - Critical Care and Emergency Medicine - Dermatology - Diabetes and Endocrinology - Ecology - Evidence-Based Healthcare - Gastroenterology and Hepatology - Geriatrics - Hematology - Immunology - Mathematics - Mental Health - Molecular Biology - Nephrology - Neurological Disorders - Neuroscience - Non-Clinical Medicine - Nutrition - Obstetrics - Oncology - Ophthalmology - Otolaryngology - Pathology - Pediatrics and Child Health - Pharmacology - Physics - Physiology - Radiology and Medical Imaging - Respiratory Medicine - Rheumatology - Science Policy - Surgery - Urology - Virology - Women's Health

Patient's Origin and Lifestyle Associated with CTX-M-Producing Escherichia coli: A Case-Control-Control Study
Published: Friday, January 27, 2012
Author: Marie-Hélène Nicolas-Chanoine et al.

by Marie-Hélène Nicolas-Chanoine, Vincent Jarlier, Jérôme Robert, Guillaume Arlet, Laurence Drieux, Véronique Leflon-Guibout, Cédric Laouénan, Béatrice Larroque, Valérie Caro, France Mentré, the study Group Coli ß


Global dissemination of Escherichia coli producing CTX-M extended-spectrum ß-lactamases (ESBL) is a public health concern. The aim of the study was to determine factors associated with CTX-M- producing E. coli infections among patients hospitalised in the Assistance Publique-Hôpitaux de Paris, the largest hospital system in France (23 000 beds), through a prospective case-control-control study.

Methods/Principal Findings

From November 2008 to June 2009, 152 inpatients with a clinical sample positive for CTX-M-producing E. coli (cases), 152 inpatients with a clinical sample positive for non ESBL-producing E. coli on the day or within the three days following case detection (controls C1), and 152 inpatients with culture-negative clinical samples since the beginning of hospitalisation and until three days after case detection (controls C2) were included in ten hospitals of the Paris area. Factors studied were related to patient's origin, lifestyle and medical history as well as care during hospitalisation. Those independently associated with CTX-M-producing E. coli were determined. Three independent factors were common to the two case-control comparisons: birth outside of Europe (cases vs C1: OR1?=?2.4; 95%CI?=?[1.3–4.5] and cases vs C2: OR2?=?3.1; 95%CI?=?[1.4–7.0]), chronic infections (OR1?=?2.9; 95%CI?=?[1.3–6.9] and OR2?=?8.7; 95%CI?=?[2.0–39.7]), and antibiotic treatment between hospital admission and inclusion (OR1?=?2.0; 95%CI?=?[1.0–3.8] and OR2?=?3.3; 95%CI?=?[1.5–7.2]). Cases were also more likely to be (i) functionally dependent before hospitalisation than C2 (OR2?=?7.0; 95%CI?=?[2.1–23.5]) and (ii) living in collective housing before hospitalisation than C2 (OR2?=?15.2; 95%CI?=?[1.8–130.7]) when CTX-M-producing E. coli was present at admission.


For the first time, patient's origin and lifestyle were demonstrated to be independently associated with isolation of CTX-M-producing E. coli, in addition to health care-related factors.