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PLoS By Category | Recent PLoS Articles
Biochemistry - Neurological Disorders - Neuroscience - Physiology - Radiology and Medical Imaging

Resting-State Brain Organization Revealed by Functional Covariance Networks
Published: Tuesday, December 13, 2011
Author: Zhiqiang Zhang et al.

by Zhiqiang Zhang, Wei Liao, Xi-Nian Zuo, Zhengge Wang, Cuiping Yuan, Qing Jiao, Huafu Chen, Bharat B. Biswal, Guangming Lu, Yijun Liu

Background

Brain network studies using techniques of intrinsic connectivity network based on fMRI time series (TS-ICN) and structural covariance network (SCN) have mapped out functional and structural organization of human brain at respective time scales. However, there lacks a meso-time-scale network to bridge the ICN and SCN and get insights of brain functional organization.

Methodology and Principal Findings

We proposed a functional covariance network (FCN) method by measuring the covariance of amplitude of low-frequency fluctuations (ALFF) in BOLD signals across subjects, and compared the patterns of ALFF-FCNs with the TS-ICNs and SCNs by mapping the brain networks of default network, task-positive network and sensory networks. We demonstrated large overlap among FCNs, ICNs and SCNs and modular nature in FCNs and ICNs by using conjunctional analysis. Most interestingly, FCN analysis showed a network dichotomy consisting of anti-correlated high-level cognitive system and low-level perceptive system, which is a novel finding different from the ICN dichotomy consisting of the default-mode network and the task-positive network.

Conclusion

The current study proposed an ALFF-FCN approach to measure the interregional correlation of brain activity responding to short periods of state, and revealed novel organization patterns of resting-state brain activity from an intermediate time scale.

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