|
Academic/Biomedical Research
News & Jobs
|
|
|
|
|
|
|
|
|
|
|
|
|
Free Newsletters
Archive
My Subscriptions
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE
Job Seeker Login
Most Recent Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers
Regional News
US & Canada
Biotech Bay
Biotech Beach
Genetown
Pharm Country
BioCapital
BioMidwest
Bio NC
BioForest
Southern Pharm
BioCanada East
US Device
Europe
Asia
Company Profiles
Research Store
Research Events
Post an Event
Real Estate
Business Opportunities
|
|
|
|
PLoS By Category | Recent
PLoS Articles
|
|
Obstetrics
|
Pregnancy and the Risk of Autoimmune Disease
Published:
Wednesday, May 18, 2011
Author:
Ali S. Khashan et al.
by Ali S. Khashan, Louise C. Kenny, Thomas M. Laursen, Uzma Mahmood, Preben B. Mortensen, Tine B. Henriksen, Keelin O'Donoghue
Autoimmune diseases (AID) predominantly affect women of reproductive age. While
basic molecular studies have implicated persisting fetal cells in the mother in
some AID, supportive epidemiological evidence is limited. We investigated the
effect of vaginal delivery, caesarean section (CS) and induced abortion on the
risk of subsequent maternal AID. Using the Danish Civil Registration System
(CRS) we identified women who were born between 1960 and1992. We performed data
linkage between the CRS other Danish national registers to identify women who
had a pregnancy and those who developed AID. Women were categorised into 4
groups; nulligravida (control group), women who had 1st child by vaginal
delivery, whose 1st delivery was by CS and who had abortions. Log-linear Poisson
regression with person-years was used for data analysis adjusting for several
potential confounders. There were 1,035,639 women aged >14 years and 25,570
developed AID: 43.4% nulligravida, 44.3% had their first pregnancy
delivered vaginally, 7.6% CS and 4.1% abortions. The risk of AID
was significantly higher in the 1st year after vaginal delivery
(RR?=?1.1[1.0, 1.2]) and CS
(RR?=?1.3[1.1, 1.5]) but significantly lower in
the 1st year following abortion (RR?=?0.7[0.6,
0.9]). These results suggest an association between pregnancy and the risk
of subsequent maternal AID. Increased risks of AID after CS may be explained by
amplified fetal cell traffic at delivery, while decreased risks after abortion
may be due to the transfer of more primitive fetal stem cells. The increased
risk of AID in the first year after delivery may also be related to greater
testing during pregnancy.
More...
|
|
|
 |
|
|
|
|
|
|
|
|