by Boyen Huang, Katsu Takahashi, Tomoko Sakata, Honoka Kiso, Manabu Sugai, Kazuma Fujimura, Akira Shimizu, Shinji Kosugi, Tosiya Sato, Kazuhisa Bessho
This study aimed to carry out a histological examination of the temporomandibular joint (TMJ) in ank mutant mice and to identify polymorphisms of the human ANKH gene in order to establish the relationship between the type of temporomandibular disorders (TMD) and ANKH polymorphisms. Materials and Methods
Specimens from the TMJ of ank mutant and wild-type mice were inspected with a haematoxylin and eosin staining method. A sample of 55 TMD patients were selected. Each was examined with standard clinical procedures and genotyping techniques. Results
The major histological finding in ank mutant mice was joint space narrowing. Within TMD patients, closed lock was more prevalent among ANKH-OR homozygotes (p?=?0.011, OR?=?7.7, 95% CI 1.6–36.5) and the elder (p?=?0.005, OR?=?2.4, 95% CI 1.3–4.3). Conclusions
Fibrous ankylosis was identified in the TMJ of ank mutant mice. In the human sample, ANKH-OR polymorphism was found to be a genetic marker associated with TMJ closed lock. Future investigations correlating genetic polymorphism to TMD are indicated.