BioSpace Collaborative

Academic/Biomedical Research
News & Jobs
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  C2C Services & Suppliers™
Europe
Asia

DIVERSITY

PROFILES
Company Profiles

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Research Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

PLoS By Category | Recent PLoS Articles
Physiology - Radiology and Medical Imaging

Left Atrial and Right Atrial Deformation in Patients with Coronary Artery Disease: A Velocity Vector Imaging-Based Study
Published: Tuesday, December 04, 2012
Author: Ping Yan et al.

by Ping Yan, Bin Sun, Haiming Shi, Wen Zhu, Qing Zhou, Yuwen Jiang, Hui Zhu, Guoqian Huang

Background

Impaired left ventricular (LV) function has been shown by strain rate (SR) imaging in patients with coronary artery disease (CAD). Our aim was to investigate global and regional, systolic and diastolic left atrial (LA) and right atrial (RA) longitudinal deformation in CAD using velocity vector imaging.

Methods

Echocardiographic and velocity vector imaging studies were performed in 20 patients with mild CAD, 40 patients with severe CAD and 25 controls. Maximal atrial volume, peak atrial longitudinal strain (es) and SR during LV systole (SRs), SR during early LV filling (SRe) and late LV filling (SRa) were measured. Longitudinal strain during atrial contraction (ea) was obtained at the onset of P-wave on electrocardiography, and ea/es was calculated.

Results

Longitudinal peak es and SRs of LA showed decreased trend among CAD patients. The global and lateral LA SRe were prominently lower, while RA ea, SRa and ea/es were prominently higher in 2 CAD groups than control group (P value <0.05). As compared with controls and patients with other single-vessel disease, LA SRa and ea/es ratio were significantly increased among patients with exclusively left anterior descending coronary artery (LAD) stenosis (SRa 1.14±0.38 s-1, 1.10±0.41 s-1, 1.45±0.46 s-1, P value<0.05; ea/es 0.44±0.11, 0.44±0.20, 0.57±0.12, P value<0.01).

Conclusions

Apparently decreased SRe of LA and increased ea, SRa and ea/es of RA were found in CAD patients with preserved LVEF and E/E' in gray zone. SRa and ea/es of LA were found to significantly increase in those with LAD stenosis.

  More...