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PLoS By Category | Recent
PLoS Articles
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Neurological Disorders - Neuroscience - Radiology and Medical Imaging
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Spontaneous Reperfusion after In Situ Thromboembolic Stroke in Mice
Published:
Friday, November 16, 2012
Author:
Anne Durand et al.
by Anne Durand, Fabien Chauveau, Tae-Hee Cho, Radu Bolbos, Jean-Baptiste Langlois, Laure Hermitte, Marlène Wiart, Yves Berthezène, Norbert Nighoghossian
Injection of thrombin into the middle cerebral artery (MCA) of mice has been proposed as a new model of thromboembolic stroke. The present study used sequential multiparametric Magnetic Resonance Imaging (MRI), including Magnetic Resonance Angiography (MRA), Diffusion-Weighted Imaging (DWI) and Perfusion-Weighted Imaging (PWI), to document MCA occlusion, PWI-DWI mismatch, and lesion development. In the first experiment, complete MCA occlusion and reproducible hypoperfusion were obtained in 85% of animals during the first hour after stroke onset. In the second experiment, 80% of animals showed partial to complete reperfusion during a three-hour follow-up. Spontaneous reperfusion thus contributed to the variability in ischemic volume in this model. The study confirmed the value of the model for evaluating new thrombolytic treatments, but calls for extended MRI follow-up at the acute stage in therapeutic studies.
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