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PLoS By Category | Recent PLoS Articles
Non-Clinical Medicine - Urology

A Genetic Variant in pre-miR-27a Is Associated with a Reduced Renal Cell Cancer Risk in a Chinese Population
Published: Tuesday, October 30, 2012
Author: Danni Shi et al.

by Danni Shi, Pu Li, Lan Ma, Dongyan Zhong, Haiyan Chu, Fu Yan, Qiang Lv, Chao Qin, Wei Wang, Meilin Wang, Na Tong, Zhengdong Zhang, Changjun Yin

Background

MicroRNAs (miRNAs) are a class of small non-coding RNAs to regulate cell differentiation, proliferation, development, and apoptosis. The single nucleotide polymorphism (SNP) rs895819 is located at the terminal loop of pre-miR-27a. Here, we aimed to investigate whether SNP rs895819 was associated with the development of renal cell cancer (RCC) in a Chinese population.

Methods

In this case-control study, we recruited 594 RCC patients and 600 cancer-free controls with frequency matched by age and sex. We genotyped this polymorphism using the TaqMan assay and assessed the effect of this polymorphism on RCC survival. Logistic regression model was used to assess the genetic effects on the development of RCC and interactions between rs895819 polymorphism and risk factors.

Results

Compared with AA homozygote, individuals carrying AG/GG genotypes had a statistically significant reduced susceptibility to RCC (adjusted OR?=?0.71, 95% CI?=?0.56–0.90). Furthermore, AG/GG genotypes were associated with reduced RCC susceptibility in localized clinical stage (adjusted OR?=?0.71, 95% CI?=?0.55–0.91), and similar effects were observed in well differentiated and poorly differentiated RCC (adjusted OR?=?0.71, 95% CI?=?0.55–0.93 for well differentiated, adjusted OR?=?0.51, 95% CI?=?0.28–0.93 for poorly differentiated). We also observed that rs895819 had multiplicative interactions with age and hypertension. However, the polymorphism did not influence the survival of RCC.

Conclusion

Our results suggest that the pre-miR-27a rs895819 polymorphism can predict RCC risk in a Chinese population. Larger population-based prospective studies should be used to validate our findings.

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