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PLoS By Category | Recent
PLoS Articles
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Immunology - Infectious Diseases - Microbiology - Ophthalmology - Pathology - Urology
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Ivermectin Inhibits Growth of Chlamydia trachomatis in Epithelial Cells
Published:
Tuesday, October 30, 2012
Author:
Matthew A. Pettengill et al.
by Matthew A. Pettengill, Verissa W. Lam, Ikechukwu Ollawa, Camila Marques-da-Silva, David M. Ojcius
Ivermectin is currently approved for treatment of both clinical and veterinary infections by nematodes, including Onchocerca cervicalis in horses and Onchocerca volvulus in humans. However, ivermectin has never been shown to be effective against bacterial pathogens. Here we show that ivermectin also inhibits infection of epithelial cells by the bacterial pathogen, Chlamydia trachomatis, at doses that could be envisioned clinically for sexually-transmitted or ocular infections by Chlamydia.
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