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PLoS By Category | Recent PLoS Articles
Gastroenterology and Hepatology - Immunology - Infectious Diseases - Pediatrics and Child Health - Pharmacology - Public Health and Epidemiology - Virology

Low Immune Response to Hepatitis B Vaccine among Children in Dakar, Senegal
Published: Wednesday, May 30, 2012
Author: Marie-Anne Rey-Cuille et al.

by Marie-Anne Rey-Cuille, Abdoulaye Seck, Richard Njouom, Loïc Chartier, Housseyn Dembel Sow, Mamadou, Amadou Sidy Ka, Mohamadou Njankouo, Dominique Rousset, Tamara Giles-Vernick, Guillemette Unal, Jean-Marie Sire, Benoît Garin, François Simon, Muriel Vray

HBV vaccine was introduced into the Expanded Programme on Immunization (EPI) in Senegal and Cameroon in 2005. We conducted a cross-sectional study in both countries to assess the HBV immune protection among children. All consecutive children under 4 years old, hospitalized for any reason between May 2009 and May 2010, with an immunisation card and a complete HBV vaccination, were tested for anti-HBs and anti-HBc. A total of 242 anti-HBc-negative children (128 in Cameroon and 114 in Senegal) were considered in the analysis. The prevalence of children with anti-HBs =10 IU/L was higher in Cameroon with 92% (95% CI: 87%–97%) compared to Senegal with 58% (95% CI: 49%–67%), (p<0.001). The response to vaccination in Senegal was lower in 2006–2007 (43%) than in 2008–2009 (65%), (p?=?0.028). Our results, although not based on a representative sample of Senegalese or Cameroonian child populations, reveal a significant problem in vaccine response in Senegal. This response problem extends well beyond hepatitis B: the same children who have not developed an immune response to the HBV vaccine are also at risk for diphtheria, tetanus, pertussis (DTwP) and Haemophilus influenzae type b (Hib). Field biological monitoring should be carried out regularly in resource-poor countries to check quality of the vaccine administered.