BioSpace Collaborative

Academic/Biomedical Research
News & Jobs
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  C2C Services & Suppliers™
Europe
Asia

DIVERSITY

PROFILES
Company Profiles

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Research Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
Get Our Industry eNewsletter FREE email:    
   

Verona Pharma Initiates Dosing in Clinical Trial to Investigate Anti-inflammatory Properties of RPL554


7/9/2012 9:35:52 AM

9 July 2012 - London, UK - London, UK - Verona Pharma plc (AIM: VRP.L), the biotechnology company focused on developing novel treatments for chronic respiratory diseases, today announces that it has commenced a new trial with its lead drug candidate, the dual PDE 3 and 4 inhibitor, RPL554.

This clinical trial is taking place at the Medicines Evaluation Unit (MEU) in Manchester, UK and is designed to test the anti-inflammatory properties of RPL554 in healthy subjects with respect to chronic obstructive pulmonary disease (“COPD”). The subjects will be treated once daily for 6 consecutive days with inhaled RPL554 before being challenged on the last day by an irritant agent that provokes an inflammatory response in their airways. The ability of RPL554 to reduce the amount of inflammation in the airways will be measured. This particular test resembles certain aspects of the airway inflammation in patients with COPD and is a common step in the development of new medicines for this disease. The study is a randomized, double-blind, placebo-controlled study that will enroll 24 subjects and is expected to finish around year-end.

Dr Jan-Anders Karlsson, CEO of Verona Pharma said: “RPL554 has the potential to become a new targeted therapy for patients with severe forms of respiratory disease. This trial at MEU is important as it is the first clinical trial designed to evaluate specifically the anti-inflammatory properties of RPL554 in human subjects. RPL554 shows unique dual bronchodilator and anti-inflammatory properties in pre-clinical models, and the company has already demonstrated that RPL554 is a bronchodilator in patients with COPD and asthma. Today there is no therapy that combines both bronchodilator and anti-inflammatory properties in one compound available to patients with respiratory diseases.”

About Verona Pharma plc

Verona Pharma plc is developing first-in-class drugs to treat respiratory disease, such as COPD, asthma and chronic severe cough. The Company has three drug programmes, two of which are in Phase II. The lead programme, RPL554, is an innovative dual phosphodiesterease (PDE) 3 and 4 inhibitor with both bronchodilator and anti-inflammatory properties. VRP700 is an innovative product for suppressing chronic severe chough in patients with underlying lung disease. In its third programme, Verona Pharma is investigating novel anti-inflammatory molecules, called NAIPs, for a wide range of respiratory and inflammatory diseases. Verona Pharma is based in London, U.K. For more information, visit: www.veronapharma.com

About chronic obstructive pulmonary disease (COPD)

COPD, commonly known as smokers’ disease, is predominantly characterized by chronic bronchitis and emphysema. It is a progressive degenerative lung disease that results in reductions in lung airflow, making it difficult to breathe. COPD is estimated to affect 210 million people worldwide and is projected to be the third leading cause of death by 2020. The economic burden of COPD in the UK is estimated to be £1.2 billion in health costs and lost productivity.

About The Medicines Evaluation Unit (MEU)

The Medicines Evaluation Unit (MEU) Ltd is one of the UK’s leading contract research organisations, working in collaboration with the University Hospital of South Manchester. The MEU specialises in performing clinical trials (from Phase I through to IV) in respiratory/inflammatory medicine and related areas. The MEU has an outstanding reputation for performing high quality clinical research complying with UK Clinical Trials Legislation and EU Directives.

For more information please contact:

Verona Pharma plc

Clive Page, Chairman

Jan-Anders Karlsson, CEO Tel: 020 7863 3300

info@veronapharma.com

WH Ireland Group Plc

Chris Fielding

Jessica Metcalf

Tel: 020 7220 1650

Chris.fielding@WH-Ireland.Co.UK

College Hill

Melanie Toyne Sewell

Gemma Howe Tel: 020 7457 2020

verona@thecollegegroup.com


Read at BioSpace.com

   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES
 

//-->