BioSpace Collaborative

Academic/Biomedical Research
News & Jobs
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

PROFILES
Company Profiles

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Research Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
Get Our Industry eNewsletter FREE email:    
   

Stunning Data for Ambit Biosciences/Astellas Pharma Inc. (YPH.BE) AML Drug


12/10/2012 8:18:52 AM

The promise shown by Ambit Biosciences' quizartinib, which is partnered with Astellas, as a treatment for acute myeloid leukaemia, has caused a stir at the American Society of Hematology meeting in Atlanta. Final results of a Phase II study of quizartinib were presented which suggest the drug may be an excellent option to treat a subset of patients with treatment-resistant AML. In the study, the majority carried a mutation in a gene called FLT3-ITD and presenting the data at ASH, Mark Levis of Johns Hopkins University, noted that the FLT3 mutation is a "power switch" that leukaemia cells use to spread more aggressively, which helps them to grow back immediately after chemotherapy. He added that the only way to treat this type of mutation "is to find a way to turn the switch off - a feat that has eluded researchers for far too long". While patients with the FLT3-ITD mutation can achieve remission with standard chemotherapy, they tend to relapse very quickly. Furthermore, an important treatment option is a stem cell transplant, but only if the patient is in some form of remission, otherwise, failure rates are high.


   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES
 

//-->