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Sofie Biosciences Launches ELIXYS, A New Generation of Automated Radiochemistry for Producing PET Imaging Probes


6/5/2012 12:01:26 PM

CULVER CITY, Calif., June 5, 2012 /PRNewswire/ -- Sofie Biosciences, Inc., a molecular imaging company offering a comprehensive range of products from pre-clinical imaging systems to new diagnostic imaging agents ("probes"), introduces ELIXYS, the newest addition to their product pipeline. Formally debuting at this week's 2012 Society for Nuclear Medicine Annual Meeting, ELIXYS is an automated radiochemistry platform for the production of a diversity of PET probes, including [18F]FAC and analogs, Sofie's proprietary class of imaging probes.

Positron Emission Tomography (PET) is a medical imaging modality that utilizes radiolabeled molecules ("probes") to target and measure biological and pharmacological processes. Basic scientists can use the same probes to visualize and characterize the biology of disease, monitor its progression, and evaluate therapeutic efficacy in cells and mice as clinicians do in patients. Over 1,600 PET probes have been developed, but only a few are routinely used. This is largely due to the complexity of synthesis, which inhibits the probe discovery and development processes in research and clinical trials. The solution to this problem requires technology innovation in radiosynthesizers, as well as breakthroughs in synthesis methods to provide rapid, site-directed labeling with high yields on a single platform capable of synthesizing a diversity of PET probes. This is also a requirement for the transition from R&D to a standardized protocol for routine production in commercial PET radiopharmacies.

ELIXYS is a novel approach to radiosynthesis. Its multi-reactor system features disposable cassettes for simplicity of operation, high-temperature and high-pressure capabilities, on-demand reagent delivery, radiation sensors and reactor vial cameras to monitor synthesis processes, between-reactor purification, an automated HPLC injection valve, and intuitive, unit operation-based software for use on tablets and smartphones, such as the iPad and iPhone. With very little effort, ELIXYS enables the end user to quickly transition between different syntheses by simply changing cassettes, reagents, and selecting software protocols.

"Fundamentally, ELIXYS is a different way to approach radiochemistry," said Patrick Phelps, Sofie's President and CEO. "ELIXYS was born out of our own need to develop and synthesize diverse classes of probes. Sofie, with our collaborators at UCLA and Caltech, are excited to share this novel technology platform with a large community of scientists and clinicians interested in expanding the diversity of PET probes to answer a vast array of biological questions."

About Sofie Biosciences
Sofie is combining the discovery and development of new PET imaging probes with the invention of innovative imaging systems to provide researchers and physicians with tools to better investigate the biology of disease. By empowering a wide array of people with valuable, translational imaging systems and probes, Sofie is making PET imaging more accessible and increasing the diversity of its applications.

For additional information on Sofie's portfolio of technologies, contact Dr. Jennifer Cho at 424.223.6948 or jennifer.cho@sofiebio.com.

SOURCE Sofie Biosciences, Inc.



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