POTSDAM, GERMANY--(Marketwire - January 20, 2012) -
Signature Diagnostics /
Signature Diagnostics to Present Detector C 2.0 - A Blood Test for Early
Detection of Colorectal Cancer at the ASCO 2012 Gastrointestinal Cancer
Symposium in San Francisco
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Potsdam, Germany, January 20, 2012 - Signature Diagnostics AG announced
today
that the company was selected to present its improved test -Detector C
2.0 for
early detection of colorectal cancer (CRC) at the ASCO 2012
Gastrointestinal
Cancer Symposium in San Francisco on January 19-21, 2012.
The paper, "Detector-c 2.0: A highly accurate blood-based IVD test for
early
detection of colorectal cancer with sensitivity and specificity over 90%."
will
be presented at the General Poster Session C on Cancers of the
Colon and
Rectum, January 21, 2012, 8:00am-9:00am and 12:00-1:30pm.
Detector C 2.0 is an improved version of the Detector C test. It
measures a
panel of 1.000 RNA markers in whole blood. Detector C 2.0 is based on a
set of
445 patients of which 291 patients were cases with confirmed CRC of all
four
stages, and 154 were healthy controls seeking a screening
colonoscopy and
underwent complete colonoscopy. Detector C 2.0 has a sensitivity of 91.6%
and a
specificity of 94.8%. Sensitivity of high-grade intraepithelial
neoplasias
(high-grade adenoma) was 67%. Detector C 2.0 is based on a 3-times
larger
patient set and shows an increase in sensitivity and specificity over
Detector C
of 1.6% and 6.8%, respectively.
Signature Diagnostics AG is a molecular diagnostics company based in
Potsdam,
Germany, focusing on the development and commercialization of novel
molecular
oncology diagnostic products for early detection (screening) and
prognosis of
cancer. The company has completed development of its first two
diagnostic
products for colorectal cancer screening ("Detector C/C+") and
prognosis
("Predictor C"), which will be launched in 2012 in its own ISO 15189
certified
service laboratory. Using its state-of-the-art technologies in tissue and
blood
sample collection, molecular pathology, Xenopatient™ platform,
genome-wide
profiling, data mining, and biostatistics, the company collaborates
with
clinical, pharmaceutical, and diagnostic partners. Signature
Diagnostics
sponsors and conducts large prospective, multicenter clinical trials with
more
than 33 primary care hospitals and several dozen colonoscopy centers in
Germany
to discover and validate biomarkers in oncology.
Press release (PDF):
http://hugin.info/143237/R/1579139/492701.pdf
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Source: Signature Diagnostics via Thomson Reuters ONE
[HUG#1579139]
