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Merus Announces the Full Validation of Its MeMo® Transgenic Mouse for Common Light Chain Human Antibodies


10/8/2012 10:59:48 AM

Utrecht, The Netherlands, October 8, 2012 – Merus B.V., a biopharmaceutical company focused on innovative human antibody therapeutics, announced today the full validation of its transgenic MeMo® mouse for common light chain human antibodies. The MeMo® mouse creates human antibody diversity using a large repertoire of human heavy chains paired with a common human light chain.

"Over the last year,

we have immunized MeMo® mice with half a dozen antigens and analyzed the immune response," said Mark Throsby, COO at Merus. "We are extremely excited by the performance of the MeMo® technology; serum antibody titers as well as size, diversity, functionality and developability of antibody panels are comparable to those of wild type mice."

“In MeMo®, a single human light chain drives the generation of a normal B cell compartment as well as supports a robust immune response,” said Ton Logtenberg, CEO and founder of Merus. “The large and diverse panels of high-quality human antibodies that we retrieve from MeMo® show that this platform is comparable to the best-in-class transgenic platforms using diversified heavy and light chains.”

Because of the common light chain, MeMo®-derived antibodies can be immediately used to rapidly generate thousands of bispecific antibodies (Biclonics™) and combinations of antibodies (Oligoclonics®) for functional screening. Merus has shown that the quality and diversity of common light chain antibodies drives the success of identifying Biclonics™ with unprecedented potencies for application in oncology. The MeMo® mouse is available for licensing.

About Merus B.V.

Merus is a biotechnology company building a pipeline of innovative human bispecific antibodies (BiclonicsTM) and single cell-derived combinations of antibodies (Oligoclonics®) for cancer therapy. Through the use of a common antibody light chain and CH3 heterodimerization technology, these full length IgG antibody therapeutics can be robustly produced at high yields from a single clonal manufacturing cell line using standard approaches. Biclonics™ and Oligoclonics® bind to multiple disease-associated targets such as growth factor receptors expressed by tumor cells. Synergy is achieved by addressing multiple pathways/mechanisms simultaneously, thereby eliminating tumor cells more efficiently and preventing treatment escape.

Merus meets a significant need in the oncology field: the supply of bispecific antibodies and single-cell derived antibody combinations with improved clinical efficacy to address the limited potency of conventional antibodies. For further information, please visit our website at www.merus.nl

Media Inquiries:

akampion

Dr. Ludger Wess or Ines-Regina Buth

Tel. +49 (0)40 88 16 59 64 / +49 (0)30 2363 2768

info(at)akampion.com

Company Inquiries:

Merus B.V.

S. Margetson - s.margetson(at)merus.nl

Padualaan 8

3584CH Utrecht, The Netherlands

Licensing inquiries:

jason.avery(at)merus.nl

Contact information:

Merus B.V.

Padualaan 8

3584CH Utrecht, The Netherlands


Read at BioSpace.com


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