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Ingenuity Systems iReport Extends Functionality With Support for Isoform-Level Human RNA Sequencing Data


10/5/2012 10:50:19 AM

REDWOOD CITY, Calif., Oct. 4, 2012 /PRNewswire/ -- Ingenuity Systems®, a leading provider of biomedical information and analysis solutions, today announced Ingenuity iReport now supports analysis and interpretation of human isoform-level RNA sequencing data. Ingenuity iReport for Isoform-level Human RNA-Seq data enables researchers to quickly and easily identify significantly regulated isoforms, interpreting the impact of those expression changes in the context of the pathways, phenotypes, and molecular interactions.

Life science researchers are rapidly adopting RNA-Seq methods for whole transcriptome analysis and identification of differentially expressed isoforms. However, data analysis and interpretation remains a challenge for researchers who find themselves faced with large, complex data sets and limited ability to generate biological insights quickly. The introduction of isoform support in iReport allows bench scientists to directly visualize and translate expression changes for individual isoforms into meaningful insights in a user-friendly web-based analysis application.

Results are supported by the Ingenuity Knowledge Base, an expert-curated repository of millions of biological and chemical findings from peer reviewed literature and commonly used databases, allowing for interpretation of results in the context of biological processes, diseases, and molecular interactions.

"Using iReport allowed us to validate our original hypothesis and then generate the next level of biological questions from our NGS datasets. We were able to quickly connect the dots and generate testable hypotheses," said John A. Martignetti, M.D., Ph.D., Mount Sinai School of Medicine. "We look forward to continuing to use iReport to further search for novel diagnostic biomarkers and candidate therapeutic targets in our ovarian cancer cohort."

"I was very impressed with the graphical representation of isoforms and the ability to see fold changes for different isoforms during inflammation from RNA sequencing data," stated Zemfira Karamysheva, Instructor, Department of Pathology, UT Southwestern Medical Center. "The new isoform iReport from Ingenuity provides information not only on biological pathways and processes for differentially expressed genes and isoforms from RNA sequencing data but also information on diseases and interactions with corresponding literature references."

iReport provides a biologist-friendly end-to-end solution for statistical and biological analysis of gene expression data including RNA-Seq, microarray, and real-time PCR data.To learn more or get a free preview of your data in iReport, go to www.ingenuity.com/getireport/.

About Ingenuity

Ingenuity® Systems is a leading provider of biomedical information and analysis solutions for the exploration, interpretation and analysis of complex biological systems in life science research and molecular diagnostics. Today, Ingenuity's solutions are used by tens of thousands of researchers and clinicians at hundreds of leading pharmaceutical, biotechnology, academic, diagnostic and clinical institutions worldwide.

SOURCE Ingenuity Systems


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