BioSpace Collaborative

Academic/Biomedical Research
News & Jobs
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  C2C Services & Suppliers™
Europe
Asia

DIVERSITY

PROFILES
Company Profiles

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Research Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
Get Our Industry eNewsletter FREE email:    
   

GlobalData Release: in Silico Therapy for Schizophrenia?


7/2/2012 12:10:04 PM

LONDON, UK (GlobalData), 2 July 2012 - With an estimated total cost of $62 billion, and $22 billion in direct healthcare costs, schizophrenia is the most expensive mental illness in the US. Moreover, a prevalence rate of about 1% of the population over the age of 18 and over 6 million people afflicted worldwide makes this a global issue for the healthcare sector.

The National Institute of Mental Health (NIMH) believes billions of dollars are lost due to time taken away from work by patients and caregivers, thus placing high demands on social services. This may be set to continue as, currently, the research pipeline is not particularly abundant, with few promising therapies filed or in Phase III development. Today, there are no curative treatments for schizophrenia, nor are there drugs specific to treating cognitive impairment.

With this said, one type of non-invasive, drug-free therapy is currently in Phase II clinical trial in the US: Brain Plasticity, Inc. (BPI) of California is spearheading the Cognitive Adaptive E-treatment in Schizophrenia-diagnosed Adults (e-CAeSAR) clinical trial in collaboration with the NIMH to evaluate a computer-based brain-plasticity program.

BPI was awarded a $3m grant from the Biomedical Research, Development and Growth to Spur the Acceleration of New Technologies Pilot Program (BRDG-SPAN), which is a program through the American Recovery & Reinvestment Act of 2009. The grant is being used to develop a software program used for cognitive remediation treatment in schizophrenia patients.

An unmet need in schizophrenia therapy is the treatment of cognitive impairment, as it is a debilitating aspect of the disease and a symptom of the illness. Cognitive function is needed to execute everyday activities such as: the ability to process information in order to make rational decisions, known as executive function; paying attention; and working memory, or the ability to use information immediately after learning it. The dysfunction of these processes can disrupt normal life and lead to emotional distress.

Brain-plasticity programs were originally developed and proven by Posit Science, located in California. BPI is designing its program based on the proven technology designed by Posit, which incorporates programs that increase the quantity of sensory information the brain absorbs, and improves the processes the brain follows in order to record the new information. By performing these exercises in the right way, brain function is strengthened, whether by expanding or shrinking, which essentially is known as brain plasticity.

Brain plasticity, a physical process involving neural connections in the brain being weakened and severed or forged and refined, occurs over time as the brain ages. These changes in the neuronal state thus lead to changes in the ability of cognitive function to process information effectively.

The e-CAeSAR study is currently recruiting adult schizophrenic patients for a multicenter, double-blind, randomized and controlled clinical trial to evaluate the safety and efficacy of plasticity-based, adaptive, computerized-based cognitive remediation therapy versus a computer-based control. The theory is that if cognitive remediation therapy is successful, patients will likely be able to regain their cognitive functions, which can lead to independence, re-entry into the workforce and increased social relationships, all of which can be extremely difficult for some patients to maintain without treatment. The National Institutes of Health (NIH) has projected it will spend close to $265m in research dollars by the end of 2012 for schizophrenia studies. The estimate for 2013 is much the same, as the NIH figures it will spend roughly the same amount of money by the end of that year. However, global research dollars are estimated to decline over the next several years.

If this is an accurate projection, the mental health research industry is likely to seek more non-invasive, drug-free therapies that aim at retraining specific brain processes such as cognitive function – an area also found to be impaired in other mental illnesses such as anxiety disorders, dementia, depression and Alzheimer’s disease.

*In Silico Therapy for Schizophrenia?

This expert insight was written by GlobalData immunology and neurology analyst, Dina Rufo. If you would like an analyst comment or to arrange an interview, please contact us on the details below.

-ABOUT GLOBALDATA-

GlobalData is a leading global business intelligence provider offering advanced analytics to help clients make better, more informed decisions every day. Our research and analysis is based on the expert knowledge of over 700 qualified business analysts and 25,000 interviews conducted with industry insiders every year, enabling us to offer the most relevant, reliable and actionable strategic business intelligence available for a wide range of industries.

Gain access to free expert analysis on the latest developments in your industry by connecting with us on:

Facebook | LinkedIn | Twitter (Healthcare) | Twitter (Energy)

For more information, please contact our Press Office on +44 (0)1204 543 537 or at pr@globaldata.com


Read at BioSpace.com

 
 

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES
 

//-->