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Epizyme Initiates Phase 1 Trial of EPZ-5676, a DOT1L Inhibitor


9/5/2012 9:47:39 AM

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Epizyme, Inc., a company leading the creation of a new class of personalized therapeutics for patients with genetically defined cancers, announced today that it has initiated a Phase 1 Study of EPZ-5676. EPZ-5676 is a novel small molecule inhibitor of DOT1L, a histone methyltransferase (HMT) that is critical to the development of a specific type of acute leukemia defined by rearrangement of the MLL gene (MLL-r leukemia). The Phase 1 study will evaluate the safety, pharmacokinetics, and pharmacodynamics of escalating doses of EPZ-5676 and will also provide a preliminary assessment of efficacy in a cohort of patients with MLL-r leukemia. Epizyme anticipates that approximately 40 patients will be accrued to this Phase 1 study.

Read at BioSpace.com


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