BioSpace Collaborative

Academic/Biomedical Research
News & Jobs
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  C2C Services & Suppliers™
Europe
Asia

DIVERSITY

PROFILES
Company Profiles

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Research Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
Get Our Industry eNewsletter FREE email:    
   

Cerecor Inc. Announces Option to Johns Hopkins Brain Science Institute DAAO Inhibitor Platform


12/6/2012 10:07:38 AM

BALTIMORE, MD--(Marketwire - December 05, 2012) - Cerecor Inc today announced that it has signed an option with Johns Hopkins University (JHU) for an exclusive license to develop and commercialize small molecule D-Amino Acid Oxidase inhibitors ("DAAO inhibitors") that were developed at the Johns Hopkins Brain Science Institute ("BSi").

DAAO inhibitors inhibit the degradation of D-serine, an amino acid which has a central role in the normal function of the glutamate / NMDA system in the human brain. Growing evidence suggests that deficits in glutamate transmission are central to the neurobiology of schizophrenia. D-serine, when administered in multi-gram quantities per day, has been shown in multiple studies to improve cognition (executive function) and reduce positive symptoms in schizophrenics. DAAO inhibition in the brain, as a means of increasing D-serine levels, has been a target for treating schizophrenia by major pharmaceutical companies for many years.

"This approach to improving glutamate transmission is to administer DAAO inhibitors systemically along with small, supplemental doses of D-serine, in a simple and elegant fashion analogous to the use of Sinemet® for the treatment of Parkinson's Disease, as originally conceptualized by Drs. Solomon Snyder and Barbara Slusher," said Dr. Blake Paterson, co-founder and CEO of Cerecor. "The licensing of the DAAO inhibitor platform will be an important milestone in the development of a novel therapeutic for schizophrenic patients, for whom persistent cognition dysfunction is widely recognized as an important gap in current therapeutic approaches."

Under the terms of the agreement with JHU, Cerecor will fund final lead selection efforts already underway at the BSi via a sponsored research agreement. Under the terms of the agreement, once BSi attains pre-specified lead candidate selection criteria, Cerecor plans to sign an exclusive, world-wide license agreement and assume development of the lead DAAO inhibitor candidate(s). JHU will receive an initial license fee and additional payments based upon achievement of specified development and commercialization milestones as well as royalties on net sales.

In 2013, Cerecor intends to complete the technology transfer activities and further examine the development and clinical profile of the lead candidate(s). This strategic evaluation will further inform potential implications for an early development clinical program.

About Cerecor: Cerecor Inc is a biopharmaceutical company focused on the discovery, development and commercialization of prescription pharmaceuticals whose primary activity is in the human nervous system. We are a Delaware corporation, based in Baltimore and co-founded in April 2011 by Drs. Solomon Snyder, Barbara Slusher, Blake Paterson and Mr. Isaac Blech. Cerecor is focused on translational medicine -- the accelerated transfer of technology from the academic laboratory to early human trials, with the mission of commercializing therapeutics that make a difference.


For More Information, contact:
John Dierkes
Kennedy Advisors
Email Contact
(410) 935-9334


Read at BioSpace.com


   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES
 

//-->