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Cancer Suppressor Gene Links Metabolism With Cellular Aging, University of Pennsylvania Study


1/14/2013 6:50:24 AM

It is perhaps impossible to overstate the importance of the tumor suppressor gene p53. It is the single most frequently mutated gene in human tumors. p53 keeps pre-cancerous cells in check by causing cells, among other things, to become senescent -- aging at the cellular level. Loss of p53 causes cells to ignore the cellular signals that would normally make mutant or damaged cells die or stop growing.

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