BioSpace Collaborative

Academic/Biomedical Research
News & Jobs
Biotechnology and Pharmaceutical Channel Medical Device and Diagnostics Channel Clinical Research Channel BioSpace Collaborative    Job Seekers:  Register | Login          Employers:  Register | Login  

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  C2C Services & Suppliers™
Europe
Asia

DIVERSITY

PROFILES
Company Profiles

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Research Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

 News | News By Subject | News by Disease News By Date | Search News
Get Our Industry eNewsletter FREE email:    
   

AEterna Zentaris (AEZS): Article on Perifosine as Potential Novel Approach to the Treatment of Mesothelioma Published in Plos One


5/31/2012 9:11:32 AM

QUÉBEC CITY, May 31, 2012 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: AEZS) (TSX: AEZ) (the "Company") today announced that an article published in the May 2012 issue of Plos One, outlines a novel mechanism of action of the Company's oral anti-cancer compound, perifosine, which could provide a rationale for a novel approach to the treatment of Malignant Pleural Mesothelioma (MMe), an aggressive type of cancer associated with exposure to asbestos. The article titled, "Perifosine as a Potential Novel Anti-Cancer Agent Inhibits EGFR/MET-AKT Axis in Malignant Pleural Mesothelioma", G. Pinton, A. Gabriella Manente, G. Angeli, L. Mutti, L. Moro, is available at www.plosone.org. Plos One is an international, peer reviewed on-line publication.

Methods

Perifosine's activity was tested on human mesothelial cells and different mesothelioma cell lines, in order to provide evidence of its efficacy as single agent and combined therapy.

Results

Data demonstrated that perifosine caused a dose-dependent reduction of Akt activation, at concentrations causing MMe cell growth arrest. Moreover, data described a novel mechanism of perifosine that interferes, upstream of Akt, affecting EGFR and MET phosphorylation. Finally, data demonstrated a significant increase in cell toxicity when MMe cells were treated with perifosine in combination with cisplatin.

Conclusions

This study provides a novel mechanism of action of perifosine, directly inhibiting EGFR/MET-Akt1/3 axis, providing a rationale for a novel translational approach to the treatment of MMe.

About Malignant Pleural Mesothelioma (MMe)

Malignant Pleural Mesothelioma is a rapidly lethal cancer associated with exposure to asbestos that is increasing in incidence worldwide. Since MMe is resistant to conventional therapies, the prognosis of these patients is poor, with a median survival of 11-12 months after diagnosis, therefore, there is an urgent need for effective therapy.

About Perifosine

Perifosine is a novel, oral anticancer compound that inhibits Akt activation in the phosphoinositide 3-kinase (PI3K) pathway. It works by interfering with membranes of cancer cells, thereby inhibiting Akt signaling which then affects cell death, growth, differentiation and survival. Perifosine is currently in a Phase 3 trial in multiple myeloma. In this indication, it has been granted Orphan Drug and Fast Track designations by the Food and Drug Administration. It has also received positive Scientific Advice and Orphan Medicinal Product designation from the European Medicines Agency. Rights for perifosine have been out licensed to Yakult Honsha Co. Ltd. for Japan, to Handok Pharmaceuticals Co. Ltd. for Korea and to Hikma Pharmaceuticals PLC for the Middle East and certain countries in North Africa. Aeterna Zentaris holds rights for the rest of the world.

About Aeterna Zentaris

Aeterna Zentaris is an oncology and endocrinology drug development company currently investigating treatments for various unmet medical needs. The Company's pipeline encompasses compounds at all stages of development, from drug discovery through to marketed products. For more information please visit www.aezsinc.com.

SOURCE AETERNA ZENTARIS INC.


Read at BioSpace.com


   

ADD TO DEL.ICIO.US    ADD TO DIGG    ADD TO FURL    ADD TO STUMBLEUPON    ADD TO TECHNORATI FAVORITES
 

//-->