Advanced Biotechnologies Inc. Introduces Quantitated PCR Control DNA For Human Polyomaviruses: JC Polyomavirus (JCV), And BK Polyomavirus (BKV)
10/19/2005 5:11:33 PM
Advanced Biotechnologies Incorporated (ABI) introduces quantitated PCR control DNA for human Polyomaviruses: JCV, catalog #08-943-250, and BKV, catalog #08-942-250.
JC virus/JCV was first isolated in 1971 from the brain tissue of a Hodgkins lymphoma patient (JC) with the demyelinating disease of the brain, progressive multifocal leukoencephalopathy (PML). BK virus/BKV was first isolated in 1970 from the urine of a renal allograft recipient (BK) with ureteric stricture.
JCV and BKV belong to the Family: Polyomaviridae, and Genus: Polyomavirus. Virions are nonenveloped, 40 nm in diameter containing supercoiled double-stranded DNA of ~5.13 kb, and have an icosahedral capsid composed of 72 capsomeres. Three structural proteins, VP 1, VP 2, and VP 3, make up the virus capsid, with VP 1 being the major component. JCV and BKV share ~70% homology in their DNA sequences.
Both JCV and BKV infections are transmitted from human to human (probably through the respiratory system), establish viremia, settle in the kidneys, and remain latent in the host. The main site of latency for JCV is B lymphocytes and for BKV is uroepithelial cells.