|Event Name||GRC 2013 Multi-Drug Efflux Systems: Shared Molecular Mechanisms but Diverging Roles in Medicine and Pharmacology
Sunday, March 17, 2013
Friday, March 22, 2013
Four Points Sheraton / Holiday Inn Express
|Description||Multi-drug resistance in bacteria has steadily risen in the past decades to become one of the major health concerns of our modern society. Much adding to this concern is that multidrug efflux systems present a frequently used and flexible means for eukaryotic and prokaryotic cells alike to resist our arsenal of once potent agents. It is from the research of the many active participants of the highly appreciated and fruitful past GRCs that our knowledge on the molecular mechanisms of transport and multi-drug recognition, genetic regulation, and pharmacological modulation has gained considerable momentum. Increasingly, we understand that complex mechanisms regulate accumulation and extrusion of xenobiotics as well as therapeutic agents in eukaryotic and prokaryotic cells. This conference will also address the multidrug uptake systems that coexist with efflux systems in determining substrate accumulation.