PLoS By Category | Recent PLoS Articles
Oncology
 
Proteomic Biomarkers for Acute Interstitial Lung Disease in Gefitinib-Treated Japanese Lung Cancer Patients  Wednesday, July 20, 2011   More...
STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia  Wednesday, July 20, 2011   More...
A Functional Proteomic Method for Biomarker Discovery  Tuesday, July 19, 2011   More...
A Novel Xenograft Model in Zebrafish for High-Resolution Investigating Dynamics of Neovascularization in Tumors  Wednesday, July 13, 2011   More...
Notch Ankyrin Repeat Domain Variation Influences Leukemogenesis and Myc Transactivation  Thursday, October 13, 2011   More...
Expression and Function of Androgen Receptor Coactivator p44/Mep50/WDR77 in Ovarian Cancer  Thursday, October 13, 2011   More...
Anatomical Differences Determine Distribution of Adenovirus after Convection-Enhanced Delivery to the Rat Brain  Thursday, October 13, 2011   More...
Hormone Receptor and ERBB2 Status in Gene Expression Profiles of Human Breast Tumor Samples  Thursday, October 13, 2011   More...
Identification and Characterization of Mechanism of Action of P61-E7, a Novel Phosphine Catalysis-Based Inhibitor of Geranylgeranyltransferase-I  Tuesday, October 18, 2011   More...
Excision Repair Cross-Complementation Group 1 (ERCC1) Status and Lung Cancer Outcomes: A Meta-Analysis of Published Studies and Recommendations  Friday, October 14, 2011   More...
Regulation of DNA Repair Mechanism in Human Glioma Xenograft Cells both In Vitro and In Vivo in Nude Mice  Friday, October 14, 2011   More...
Reproducible Cancer Biomarker Discovery in SELDI-TOF MS Using Different Pre-Processing Algorithms  Friday, October 14, 2011   More...
Recruitment and Activation of Pancreatic Stellate Cells from the Bone Marrow in Pancreatic Cancer: A Model of Tumor-Host Interaction  Friday, October 14, 2011   More...
Nuclear GRP75 Binds Retinoic Acid Receptors to Promote Neuronal Differentiation of Neuroblastoma  Friday, October 14, 2011   More...
Fluorescent Peptide Biosensor for Probing the Relative Abundance of Cyclin-Dependent Kinases in Living Cells  Tuesday, October 18, 2011   More...
Galectin-1-Binding Glycoforms of Haptoglobin with Altered Intracellular Trafficking, and Increase in Metastatic Breast Cancer Patients  Tuesday, October 18, 2011   More...
Matrix Metalloproteinase-10 Promotes Kras-Mediated Bronchio-Alveolar Stem Cell Expansion and Lung Cancer Formation  Monday, October 17, 2011   More...
RNA-Seq Analyses Generate Comprehensive Transcriptomic Landscape and Reveal Complex Transcript Patterns in Hepatocellular Carcinoma  Monday, October 17, 2011   More...
HURP Expression-Assisted Risk Scores Identify Prognosis Distinguishable Subgroups in Early Stage Liver Cancer  Monday, October 17, 2011   More...
Downregulation of RPL6 by siRNA Inhibits Proliferation and Cell Cycle Progression of Human Gastric Cancer Cell Lines  Monday, October 17, 2011   More...
Auto-Antibodies to ß-F1-ATPase and Vimentin in Malignant Mesothelioma  Monday, October 17, 2011   More...
miRConnect: Identifying Effector Genes of miRNAs and miRNA Families in Cancer Cells  Wednesday, October 26, 2011   More...
The Tyrosine Kinase Inhibitor Dasatinib Induces a Marked Adipogenic Differentiation of Human Multipotent Mesenchymal Stromal Cells  Friday, December 02, 2011   More...
Membrane-Type-3 Matrix Metalloproteinase (MT3-MMP) Functions as a Matrix Composition-Dependent Effector of Melanoma Cell Invasion  Friday, December 02, 2011   More...
Automatic Tumor-Stroma Separation in Fluorescence TMAs Enables the Quantitative High-Throughput Analysis of Multiple Cancer Biomarkers  Friday, December 02, 2011   More...
Aberrant Hedgehog Ligands Induce Progressive Pancreatic Fibrosis by Paracrine Activation of Myofibroblasts and Ductular Cells in Transgenic Zebrafish  Friday, December 02, 2011   More...
Autophagy Inhibition Enhances Daunorubicin-Induced Apoptosis in K562 Cells  Friday, December 02, 2011   More...
Constitutive MAP Kinase Activation in Hematopoietic Stem Cells Induces a Myeloproliferative Disorder  Friday, December 02, 2011   More...
miRNA Expression Profiling of the Murine TH-MYCN Neuroblastoma Model Reveals Similarities with Human Tumors and Identifies Novel Candidate MiRNAs  Friday, December 02, 2011   More...
Cross-Talk between the Cellular Redox State and the Circadian System in Neurospora  Friday, December 02, 2011   More...
Assessment of a Novel VEGF Targeted Agent Using Patient-Derived Tumor Tissue Xenograft Models of Colon Carcinoma with Lymphatic and Hepatic Metastases  Friday, December 02, 2011   More...
Schisandrin B Prevents Doxorubicin-Induced Chronic Cardiotoxicity and Enhances Its Anticancer Activity In Vivo  Friday, December 02, 2011   More...
PTEN Modulates miR-21 Processing via RNA-Regulatory Protein RNH1  Monday, December 05, 2011   More...
Small Interfering RNA against Transcription Factor STAT6 Leads to Increased Cholesterol Synthesis in Lung Cancer Cell Lines  Monday, December 05, 2011   More...
Investigations on the Usefulness of CEACAMs as Potential Imaging Targets for Molecular Imaging Purposes  Monday, December 05, 2011   More...
Gene Transfer Using Micellar Nanovectors Inhibits Choroidal Neovascularization In Vivo  Monday, December 05, 2011   More...
Mannose Receptor (MR) Engagement by Mesothelin GPI Anchor Polarizes Tumor-Associated Macrophages and Is Blocked by Anti-MR Human Recombinant Antibody  Tuesday, December 06, 2011   More...
Upregulation of the Cell-Cycle Regulator RGC-32 in Epstein-Barr Virus-Immortalized Cells  Tuesday, December 06, 2011   More...
Disabled-1 Alternative Splicing in Human Fetal Retina and Neural Tumors  Tuesday, December 06, 2011   More...
Whole Transcriptome RNA-Seq Analysis of Breast Cancer Recurrence Risk Using Formalin-Fixed Paraffin-Embedded Tumor Tissue  Friday, July 13, 2012   More...
A Role for PP1/NIPP1 in Steering Migration of Human Cancer Cells  Monday, July 16, 2012   More...
Physalin F Induces Cell Apoptosis in Human Renal Carcinoma Cells by Targeting NF-kappaB and Generating Reactive Oxygen Species  Monday, July 16, 2012   More...
Cranial Irradiation Alters Dendritic Spine Density and Morphology in the Hippocampus  Monday, July 16, 2012   More...
Simulating Molecular Mechanisms of the MDM2-Mediated Regulatory Interactions: A Conformational Selection Model of the MDM2 Lid Dynamics  Monday, July 16, 2012   More...
Evaluation of a Gene-Directed Enzyme-Product Therapy (GDEPT) in Human Pancreatic Tumor Cells and Their Use as In Vivo Models for Pancreatic Cancer  Monday, July 16, 2012   More...
Alleviation of Gut Inflammation by Cdx2/Pxr Pathway in a Mouse Model of Chemical Colitis  Monday, July 16, 2012   More...
Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer  Monday, July 16, 2012   More...
HPV Genotyping and Site of Viral Integration in Cervical Cancers in Indian Women  Monday, July 16, 2012   More...
A Cross-Platform Comparison of Genome-Wide Expression Changes of Laser Microdissected Lung Tissue of C-Raf Transgenic Mice Using 3'IVT and Exon Array  Monday, July 16, 2012   More...
Distinct Genes Related to Drug Response Identified in ER Positive and ER Negative Breast Cancer Cell Lines  Monday, July 16, 2012   More...
Upregulator of Cell Proliferation Predicts Poor Prognosis in Hepatocellular Carcinoma and Contributes to Hepatocarcinogenesis by Downregulating FOXO3a  Monday, July 16, 2012   More...
Methylomic Analysis Identifies Frequent DNA Methylation of Zinc Finger Protein 582 (ZNF582) in Cervical Neoplasms  Monday, July 16, 2012   More...
Decreased Expression of SATB2: A Novel Independent Prognostic Marker of Worse Outcome in Laryngeal Carcinoma Patients  Monday, July 16, 2012   More...
Synergistic Effect between Alcohol Consumption and Familial Susceptibility on Lung Cancer Risk among Chinese Men  Monday, July 16, 2012   More...
Mitochondrial Genome Variations in Advanced Stage Endometriosis: A Study in South Indian Population  Tuesday, July 17, 2012   More...
Reduced Susceptibility to Colitis-Associated Colon Carcinogenesis in Mice Lacking Plasma Membrane-Associated Sialidase  Tuesday, July 17, 2012   More...
Combination of Sulindac and Dichloroacetate Kills Cancer Cells via Oxidative Damage  Tuesday, July 17, 2012   More...
Loss of Activating EGFR Mutant Gene Contributes to Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer Cells  Tuesday, July 17, 2012   More...
The Aryl Hydrocarbon Receptor Mediates Leflunomide-Induced Growth Inhibition of Melanoma Cells  Tuesday, July 17, 2012   More...
Met Receptor Tyrosine Kinase Signaling Induces Secretion of the Angiogenic Chemokine Interleukin-8/CXCL8 in Pancreatic Cancer  Tuesday, July 17, 2012   More...
A Functional NQO1 609C>T Polymorphism and Risk of Gastrointestinal Cancers: A Meta-Analysis  Tuesday, January 17, 2012   More...
Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer  Tuesday, January 17, 2012   More...
Anti-Tumor Effect against Human Cancer Xenografts by a Fully Human Monoclonal Antibody to a Variant 8-Epitope of CD44R1 Expressed on Cancer Stem Cells  Tuesday, January 17, 2012   More...
Fluoxetine Counteracts the Cognitive and Cellular Effects of 5-Fluorouracil in the Rat Hippocampus by a Mechanism of Prevention Rather than Recovery  Tuesday, January 17, 2012   More...
TWIST1 a New Determinant of Epithelial to Mesenchymal Transition in EGFR Mutated Lung Adenocarcinoma  Tuesday, January 17, 2012   More...
The Role of EZH2 in the Regulation of the Activity of Matrix Metalloproteinases in Prostate Cancer Cells  Tuesday, January 17, 2012   More...
Identification of a Potential Ovarian Cancer Stem Cell Gene Expression Profile from Advanced Stage Papillary Serous Ovarian Cancer  Tuesday, January 17, 2012   More...
Impact of Circulating Cholesterol Levels on Growth and Intratumoral Androgen Concentration of Prostate Tumors  Wednesday, January 18, 2012   More...
Mitochondrial Apoptosis and FAK Signaling Disruption by a Novel Histone Deacetylase Inhibitor, HTPB, in Antitumor and Antimetastatic Mouse Models  Wednesday, January 18, 2012   More...
Chemotaxis of Cell Populations through Confined Spaces at Single-Cell Resolution  Wednesday, January 18, 2012   More...
A New Model for Raf Kinase Inhibitory Protein Induced Chemotherapeutic Resistance  Wednesday, January 18, 2012   More...
A Meta-Analysis of Interleukin-8 -251 Promoter Polymorphism Associated with Gastric Cancer Risk  Wednesday, January 18, 2012   More...
Association between the Perioperative Antioxidative Ability of Platelets and Early Post-Transplant Function of Kidney Allografts: A Pilot Study  Wednesday, January 18, 2012   More...
Dissecting the Autocrine and Paracrine Roles of the CCR2-CCL2 Axis in Tumor Survival and Angiogenesis  Wednesday, January 18, 2012   More...
Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells  Wednesday, January 18, 2012   More...
Whole Brain Radiation-Induced Impairments in Learning and Memory Are Time-Sensitive and Reversible by Systemic Hypoxia  Wednesday, January 18, 2012   More...
Contribution of HOGG1 Ser326Cys Polymorphism to the Development of Prostate Cancer in Smokers: Meta-Analysis of 2779 Cases and 3484 Controls  Wednesday, January 18, 2012   More...
The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer  Wednesday, January 18, 2012   More...
Imaging the Impact of Chemically Inducible Proteins on Cellular Dynamics In Vivo  Thursday, January 19, 2012   More...
Lack of Effect of Lowering LDL Cholesterol on Cancer: Meta-Analysis of Individual Data from 175,000 People in 27 Randomised Trials of Statin Therapy  Thursday, January 19, 2012   More...
Expression of the Stress Response Oncoprotein LEDGF/p75 in Human Cancer: A Study of 21 Tumor Types  Thursday, January 19, 2012   More...
Prognosis of Sentinel Node Staged Patients with Primary Cutaneous Melanoma  Thursday, January 19, 2012   More...
A Novel Volume-Age-KPS (VAK) Glioblastoma Classification Identifies a Prognostic Cognate microRNA-Gene Signature  Friday, August 03, 2012   More...
SPARC Is a Key Regulator of Proliferation, Apoptosis and Invasion in Human Ovarian Cancer  Friday, August 03, 2012   More...
Cancer Incidence among Adolescents and Young Adults in Urban Shanghai, 1973–2005  Friday, August 03, 2012   More...
High-Throughput Genotyping in Metastatic Esophageal Squamous Cell Carcinoma Identifies Phosphoinositide-3-Kinase and BRAF Mutations  Friday, August 03, 2012   More...
Identification of CD166 as a Surface Marker for Enriching Prostate Stem/Progenitor and Cancer Initiating Cells  Friday, August 03, 2012   More...
Identification of CBX3 and ABCA5 as Putative Biomarkers for Tumor Stem Cells in Osteosarcoma  Friday, August 03, 2012   More...
Carboxyamidotriazole-Orotate Inhibits the Growth of Imatinib-Resistant Chronic Myeloid Leukaemia Cells and Modulates Exosomes-Stimulated Angiogenesis  Friday, August 03, 2012   More...
Spontaneous Cancer-Stromal Cell Fusion as a Mechanism of Prostate Cancer Androgen-Independent Progression  Friday, August 03, 2012   More...
BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines  Friday, August 03, 2012   More...
In Vitro and In Vivo Prostate Cancer Metastasis and Chemoresistance Can Be Modulated by Expression of either CD44 or CD147  Friday, August 03, 2012   More...
Risk of Hormone Escape in a Human Prostate Cancer Model Depends on Therapy Modalities and Can Be Reduced by Tyrosine Kinase Inhibitors  Monday, August 06, 2012   More...
MicroRNA-30b-Mediated Regulation of Catalase Expression in Human ARPE-19 Cells  Monday, August 06, 2012   More...
LncRNAs Expression Signatures of Renal Clear Cell Carcinoma Revealed by Microarray  Monday, August 06, 2012   More...
The Guanine-Quadruplex Structure in the Human c-myc Gene's Promoter Is Converted into B-DNA Form by the Human Poly(ADP-Ribose)Polymerase-1  Monday, August 06, 2012   More...
Prognostic Impact of FoxP3+ Regulatory T Cells in Relation to CD8+ T Lymphocyte Density in Human Colon Carcinomas  Monday, August 06, 2012   More...
Genomic Aberrations in an African American Colorectal Cancer Cohort Reveals a MSI-Specific Profile and Chromosome X Amplification in Male Patients  Monday, August 06, 2012   More...
Aging of the Microenvironment Influences Clonality in Hematopoiesis  Monday, August 06, 2012   More...
Treatment-Related Death in Patients with Small-Cell Lung Cancer in Phase III Trials over the Last Two Decades  Monday, August 06, 2012   More...
In Vitro Generation of Monocyte-Derived Macrophages under Serum-Free Conditions Improves Their Tumor Promoting Functions  Monday, August 06, 2012   More...
Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model  Monday, August 06, 2012   More...
Selfish Spermatogonial Selection: Evidence from an Immunohistochemical Screen in Testes of Elderly Men  Monday, August 06, 2012   More...
Bispecific Engineered Antibody Domains (Nanoantibodies) That Interact Noncompetitively with an HIV-1 Neutralizing Epitope and FcRn  Tuesday, August 07, 2012   More...
Understanding the Basis of Drug Resistance of the Mutants of aß-Tubulin Dimer via Molecular Dynamics Simulations  Tuesday, August 07, 2012   More...
iNKT Cells Suppress the CD8+ T Cell Response to a Murine Burkitt’s-Like B Cell Lymphoma  Tuesday, August 07, 2012   More...
Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)  Tuesday, August 07, 2012   More...
Mouse p53-Deficient Cancer Models as Platforms for Obtaining Genomic Predictors of Human Cancer Clinical Outcomes  Tuesday, August 07, 2012   More...
Mood Disorders and Risk of Lung Cancer in the EAGLE Case-Control Study and in the U.S. Veterans Affairs Inpatient Cohort  Tuesday, August 07, 2012   More...
Functional Dissection of HOXD Cluster Genes in Regulation of Neuroblastoma Cell Proliferation and Differentiation  Tuesday, August 07, 2012   More...
Detection of IGF2BP3, HOXB7, and NEK2 mRNA Expression in Brush Cytology Specimens as a New Diagnostic Tool in Patients with Biliary Strictures  Tuesday, August 07, 2012   More...
Evaluation of Human Leukocyte Antigen-A (HLA-A), Other Non-HLA Markers on Chromosome 6p21 and Risk of Nasopharyngeal Carcinoma  Tuesday, August 07, 2012   More...
Upregulation of MircoRNA-370 Induces Proliferation in Human Prostate Cancer Cells by Downregulating the Transcription Factor FOXO1  Tuesday, September 18, 2012   More...
Trajectories of Quality of Life among Chinese Patients Diagnosed with Nasopharynegeal Cancer  Tuesday, September 18, 2012   More...
Patterns and Possible Roles of LINE-1 Methylation Changes in Smoke-Exposed Epithelia  Tuesday, September 18, 2012   More...
Loss of Expression and Function of SOCS3 Is an Early Event in HNSCC: Altered Subcellular Localization as a Possible Mechanism Involved in Proliferation, Migration and Invasion  Tuesday, September 18, 2012   More...
Combined, Sequential Intravenous and Intra-Arterial Chemotherapy (Bridge Chemotherapy) for Young Infants with Retinoblastoma  Tuesday, September 18, 2012