by Yuqian Bao, Zhigang Lu, Mi Zhou, Huating Li, Ye Wang, Meifang Gao, Meng Wei, Weiping Jia
Adipocyte fatty acid-binding protein (A-FABP) has been described as a novel adipokine, playing an important role in the development of metabolic syndrome, type 2 diabetes and atherosclerosis. In this study, we investigated the relationship between serum levels of A-FABP and the presence and severity of coronary artery disease (CAD) in Chinese subjects. Methodology/Principal Findings
Circulating A-FABP level was determined by ELISA in 341 Chinese subjects (221 men, 120 women) who underwent coronary angiography. A-FABP levels in patients with CAD were significantly higher compared with non-CAD subjects (P?=?0.029 in men; P?=?0.031 in women). Serum A-FABP increased significantly in multi-vessel diseased patients than in non-CAD subjects (P?=?0.011 in men, P?=?0.004 in women), and showed an independent correlation with coronary atherosclerosis index (standardized ß?=?0.173, P?=?0.025). In multiple logistic regression analysis, serum A-FABP was an independent risk factor for CAD in women (OR?=?5.637, 95%CI: 1.299-24.457, P?=?0.021). In addition, amino terminal pro-brain natriuretic peptide (NT-proBNP) was demonstrated to be positively and independently correlated with A-FABP (standardized ß?=?0.135, P?=?0.027). Conclusions/Significance
Serum A-FABP is closely associated with the presence and severity of CAD in Chinese women.