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Biochemistry - Critical Care and Emergency Medicine - Diabetes and Endocrinology - Nephrology - Non-Clinical Medicine - Physiology

Safety Issues of Long-Term Glucose Load in Patients on Peritoneal Dialysis—A 7-Year Cohort Study
Published: Monday, January 23, 2012
Author: Hon-Yen Wu et al.

by Hon-Yen Wu, Kuan-Yu Hung, Tao-Min Huang, Fu-Chang Hu, Yu-Sen Peng, Jenq-Wen Huang, Shuei-Liong Lin, Yung-Ming Chen, Tzong-Shinn Chu, Tun-Jun Tsai, Kwan-Dun Wu


Effects of long-term glucose load on peritoneal dialysis (PD) patient safety and outcomes have seldom been reported. This study demonstrates the influence of long-term glucose load on patient and technique survival.


We surveyed 173 incident PD patients. Long-term glucose load was evaluated by calculating the average dialysate glucose concentration since initiation of PD. Risk factors were assessed by fitting Cox's models with repeatedly measured time-dependent covariates.


We noted that older age, higher glucose concentration, and lower residual renal function (RRF) were significantly associated with a worse patient survival. We found that female gender, absence of diabetes, lower glucose concentration, use of icodextrin, higher serum high density lipoprotein cholesterol, and higher RRF were significantly associated with a better technique survival.


Long-term glucose load predicted mortality and technique failure in chronic PD patients. These findings emphasize the importance of minimizing glucose load in PD patients.