PLoS By Category | Recent PLoS Articles


Iodine Deficiency in Northern Paris Area: Impact on Fetal Thyroid Mensuration
Published: Wednesday, February 16, 2011
Author: Dominique Luton et al.

by Dominique Luton, Corinne Alberti, Edith Vuillard, Guillaume Ducarme, Jean François Oury, Jean Guibourdenche


Iodine is essential for normal fetal and neonatal development. We studied the prevalence and impact on fetal thyroid development of iodine deficiency in pregnant women in the northern part of the Paris conurbation.

Materials and Methods

110 patients underwent several determinations of urinary iodine excretion (UIE) and of serum FT4, FT3, and TSH. Fetal thyroid gland size was assessed using ultrasonography.


We found evidence of widespread iodine deficiency (mean UIE, 49.8 µg/L [standard deviation, 2.11]). Iodine deficiency did not correlate significantly with maternal thyroid parameters but showed a significant negative correlation with fetal thyroid gland size (rho?=?0.25, P?=?0.02).


Iodine deficiency during pregnancy is still a problem in our geographical area and affects the fetal thyroid gland.Clinical NCT00162539