PLoS By Category | Recent PLoS Articles

Biochemistry - Ophthalmology - Public Health and Epidemiology

Dyslipidemia and Eye Diseases in the Adult Chinese Population: The Beijing Eye Study
Published: Friday, October 28, 2011
Author: Shuang Wang et al.

by Shuang Wang, Liang Xu, Jost B. Jonas, Ya Xing Wang, Qi Sheng You, Hua Yang

To determine associations between dyslipidemia and ocular diseases, the population-based Beijing Eye Study 2006 examined 3251 subjects (age=45 years) who underwent a detailed ophthalmic examination and biochemical blood analysis. Dyslipidemia was defined as any of the following: hypercholesterolemia (total cholesterol concentration=5.72 mmol/L (220 mg/dL)) or hypertriglyceridemia (triglyceride concentration=1.70 mmol/L (150 mg/dL)) or low high-density lipoprotein-cholesterol (HDL-C concentration=0.91 mmol/L (35 mg/dL)). Biochemical blood examinations were available for 2945 (90.6%) subjects. After adjustment for age, gender, habitation region, body mass index, self reported income, blood glucose concentration, diastolic blood pressure and smoking, dyslipidemia was significantly associated with higher intraocular pressure (P<0.001) and beta zone of parapapillary atrophy (P?=?0.03). Dyslipidemia was not significantly associated with the prevalence of glaucoma (P?=?0.99), retinal vein occlusions (P?=?0.92), diabetic retinopathy (P?=?0.49), presence of retinal vascular abnormalities such as focal or general arteriolar narrowing, age-related macular degeneration (P?=?0.27), nuclear cataract (P?=?0.14), cortical cataract (P?=?0.93), and subcapsular cataract (P?=?0.67). The results make one conclude that, controlled for systemic and socioeconomic parameters, dyslipidemia was not associated with common ophthalmic disorders including glaucoma and age-related macular degeneration.