BioSpace - Vaccination of Lactating Dairy Cows for the Prevention of Aflatoxin B1 Carry Over in Milk

Biotech and Pharmaceutical
News & Jobs

Search the Site

Employers
Post Job | Search Resumes | Login

NEWSLETTERS
Free Newsletters
Archive
My Subscriptions

NEWS
News by Subject
News by Disease
News by Date
PLoS
Search News
Post Your News
JoVE

CAREER NETWORK
Job Seeker Login
Most Recent Jobs
Browse Biotech Jobs
Search Jobs
Post Resume
Career Fairs
Career Resources
For Employers

HOTBEDS
Regional News
US & Canada
  Biotech Bay
  Biotech Beach
  Genetown
  Pharm Country
  BioCapital
  BioMidwest
  Bio NC
  BioForest
  Southern Pharm
  BioCanada East
  US Device
Europe
Asia

DIVERSITY

INVESTOR
Market Summary
News
IPOs

PROFILES
Company Profiles

START UPS
Companies
Events

INTELLIGENCE
Research Store

INDUSTRY EVENTS
Biotech Events
Post an Event
RESOURCES
Real Estate
Business Opportunities

PLoS By Category | Recent PLoS Articles

Biochemistry - Chemistry - Gastroenterology and Hepatology - Immunology - Nutrition - Oncology - Pharmacology

Vaccination of Lactating Dairy Cows for the Prevention of Aflatoxin B1 Carry Over in Milk
Published: Friday, October 28, 2011
Author: Luciano Polonelli et al.

by Luciano Polonelli, Laura Giovati, Walter Magliani, Stefania Conti, Stefano Sforza, Alessandro Calabretta, Claudio Casoli, Paola Ronzi, Ester Grilli, Antonio Gallo, Francesco Masoero, Gianfranco Piva

The potential of anaflatoxin B₁ (AnAFB₁) conjugated to keyhole limpet hemocyanin (KLH) as a vaccine (AnAFB₁-KLH) in controlling the carry over of the aflatoxin B₁ (AFB₁) metabolite aflatoxin M₁ (AFM₁) in cow milk is reported. AFB₁ is the most carcinogenic compound in food and foodstuffs amongst aflatoxins (AFs). AnAFB₁ is AFB₁ chemically modified as AFB₁-1(O-carboxymethyl) oxime. In comparison to AFB₁, AnAFB₁ has proven to be non-toxic in vitro to human hepatocarcinoma cells and non mutagenic to Salmonella typhimurium strains. AnAFB₁-KLH was used for immunization of cows proving to induce a long lasting titer of anti-AFB₁ IgG antibodies (Abs) which were cross reactive with AFB₁, AFG₁, and AFG₂. The elicited anti-AFB₁ Abs were able to hinder the secretion of AFM₁ into the milk of cows continuously fed with AFB₁. Vaccination of lactating animals with conjugated AnAFB₁ may represent a solution to the public hazard constituted by milk and cheese contaminated with AFs. More...