PLoS By Category | Recent PLoS Articles

Radiology and Medical Imaging - Women's Health

Clinical Implication of Coronary Tortuosity in Patients with Coronary Artery Disease
Published: Wednesday, August 31, 2011
Author: Yang Li et al.

by Yang Li, Chengxing Shen, Yanan Ji, Yi Feng, Genshan Ma, Naifeng Liu


Coronary tortuosity (CT) is a common coronary angiography finding. The exact pathogenesis, clinical implication and long-term prognosis of CT are not fully understood. The purpose of this study is to investigate the clinical characteristics of CT in patients with suspected coronary artery disease(CAD) in a Chinese population.


A total of 1010 consecutive patients underwent coronary angiography with complaints of chest pain or related symptoms were included in the present study (544 male, mean age: 64±11 years). CT was defined by the finding of =3 bends (defined as =45° change in vessel direction) along main trunk of at least one artery in systole and in diastole. Patients with or without CAD were further divided into CT-positive and CT-negative groups, all patients were followed up for the incidence of major adverse cardiovascular events (MACE) for 2 to 4 years.


The prevalence of CT was 39.1% in this patient cohort and incidence of CT was significantly higher in female patients than that in male patients (OR?=?2.603, 95%CI 1.897, 3.607, P<0.001). CT was positively correlated with essential hypertension (OR?=?1.533, 95%CI 1.131, 2.076, P?=?0.006) and negatively correlated with CAD (OR?=?0.755, 95%CI 0.574, 0.994, P?=?0.045). MACE during follow up was similar between CAD patients with or without CT.


CT is more often seen in females and positively correlated with hypertension and negatively correlated with coronary atherosclerosis.