PLoS By Category | Recent PLoS Articles

Anesthesiology and Pain Management - Mathematics - Physics

Cortico-Cardio-Respiratory Network Interactions during Anesthesia
Published: Wednesday, September 19, 2012
Author: Yuri Shiogai et al.

by Yuri Shiogai, Mukesh Dhamala, Kumiko Oshima, Martin Hasler

General anesthetics are used during medical and surgical procedures to reversibly induce a state of total unconsciousness in patients. Here, we investigate, from a dynamic network perspective, how the cortical and cardiovascular systems behave during anesthesia by applying nonparametric spectral techniques to cortical electroencephalography, electrocardiogram and respiratory signals recorded from anesthetized rats under two drugs, ketamine-xylazine (KX) and pentobarbital (PB). We find that the patterns of low-frequency cortico-cardio-respiratory network interactions may undergo significant changes in network activity strengths and in number of network links at different depths of anesthesia dependent upon anesthetics used.