PLoS By Category | Recent PLoS Articles

Diabetes and Endocrinology - Pediatrics and Child Health - Respiratory Medicine

Glucose Tolerance during Pulmonary Exacerbations in Children with Cystic Fibrosis
Published: Thursday, September 13, 2012
Author: John Widger et al.

by John Widger, Mark R. Oliver, Michele O’Connell, Fergus J. Cameron, Sarath Ranganathan, Phil J. Robinson


Patients with Cystic Fibrosis (CF) are relatively insulinopenic and are at risk of diabetes, especially during times of stress. There is a paucity of data in the literature describing glucose tolerance during CF pulmonary exacerbations. We hypothesised that glucose tolerance would be worse during pulmonary exacerbations in children with CF than during clinical stability.


Patients with CF, 10 years or older, admitted with a pulmonary exacerbation underwent an OGTT within 48 hours of admission. A repeat OGTT was performed 4 to 6 weeks post discharge when the patients were well.


Nine patients completed the study. Four patients were found to have normal glucose tolerance, 3 with impaired and 2 with CF related diabetes during the exacerbation. Mean change in 2-hour glucose was 1.1 mmol (SD?=?0.77). At the follow up OGTT, 8 of 9 (89%) remained within their respective glucose tolerance status groupings.


The findings of this study show that there is little difference in glucose tolerance during CF exacerbations compared to clinical stability in the majority of patients.