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Respiratory Medicine

Transcriptional Programs Controlling Perinatal Lung Maturation
Published: Monday, August 20, 2012
Author: Yan Xu et al.

by Yan Xu, Yanhua Wang, Valérie Besnard, Machiko Ikegami, Susan E. Wert, Caleb Heffner, Stephen A. Murray, Leah Rae Donahue, Jeffrey A. Whitsett

The timing of lung maturation is controlled precisely by complex genetic and cellular programs. Lung immaturity following preterm birth frequently results in Respiratory Distress Syndrome (RDS) and Broncho-Pulmonary Dysplasia (BPD), which are leading causes of mortality and morbidity in preterm infants. Mechanisms synchronizing gestational length and lung maturation remain to be elucidated. In this study, we designed a genome-wide mRNA expression time-course study from E15.5 to Postnatal Day 0 (PN0) using lung RNAs from C57BL/6J (B6) and A/J mice that differ in gestational length by ~30 hr (B6