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Chemistry - Gastroenterology and Hepatology - Surgery - Urology

Profiling Circulating and Urinary Bile Acids in Patients with Biliary Obstruction before and after Biliary Stenting
Published: Friday, July 08, 2011
Author: Jocelyn Trottier et al.

by Jocelyn Trottier, Andrzej Bialek, Patrick Caron, Robert J. Straka, Piotr Milkiewicz, Olivier Barbier


These results demonstrate that biliary obstruction affects differentially the circulating and/or urinary levels of the various bile acids. The observation that the most drastically affected acids correspond to the less toxic species supports the activation of self-protecting mechanisms aimed at limiting the inherent toxicity of bile acids in face of biliary obstruction.