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PLoS By Category | Recent PLoS Articles
Gastroenterology and Hepatology - Oncology - Surgery

Transthoracic Resection versus Non-Transthoracic Resection for Gastroesophageal Junction Cancer: A Meta-Analysis
Published: Monday, June 04, 2012
Author: Kun Yang et al.

by Kun Yang, Hai-Ning Chen, Xin-Zu Chen, Qing-Chun Lu, Lin Pan, Jie Liu, Bin Dai, Bo Zhang, Zhi-Xin Chen, Jia-Ping Chen, Jian-Kun Hu

Background

The aim of this meta-analysis is to evaluate the impact of transthoracic resection on long-term survival of patients with GEJ cancer and to compare the postoperative morbidity and mortality of patients undergoing transthoracic resection with those of patients who were not undergoing transthoracic resection.

Method

Searches of electronic databases identifying studies from Medline, Cochrane Library trials register, and WHO Trial Registration etc were performed. Outcome measures were survival, postoperative morbidity and mortality, and operation related events.

Results

Twelve studies (including 5 RCTs and 7 non-RCTs) comprising 1105 patients were included in this meta-analysis, with 591 patients assigned treatment with transthoracic resection. Transthoracic resection did not increase the 5-y overall survival rate for RCTs and non-RCTs (HR?=?1.01, 95% CI 0.80- 1.29 and HR?=?0.89, 95% CI 0.70- 1.14, respectively). Stratified by the Siewert classification, our result showed no obvious differences were observed between the group with transthoracic resection and group without transthoracic resection (P>0.05). The postoperative morbidity (RR?=?0.69, 95% CI 0.48- 1.00 and OR?=?0.55, 95% CI 0.25- 1.22) and mortality (RD?=? -0.03, 95% CI -0.06- 0.00 and RD?=?0.00, 95% CI -0.05- 0.05) of RCTs and non-RCTs did not suggest any significant differences between the two groups. Hospital stay was long with thransthoracic resection (WMD?=? -5.80, 95% CI -10.38- -1.23) but did not seem to differ in number of harvested lymph nodes, operation time, blood loss, numbers of patients needing transfusion, and reoperation rate. The results of sensitivity analyses were similar to the primary analyses.

Conclusions

There were no significant differences of survival rate and postoperative morbidity and mortality between transthoracic resection group and non-transthoracic resection group. Both surgical approaches are acceptable, and that one offers no clear advantage over the other. However, the results should be interpreted cautiously since the qualities of included studies were suboptimal.

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