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Hematology - Oncology - Public Health and Epidemiology

Tumor Necrosis Factor-a Induced Protein 8 Polymorphism and Risk of Non-Hodgkin’s Lymphoma in a Chinese Population: A Case-Control Study
Published: Tuesday, May 29, 2012
Author: Yan Zhang et al.

by Yan Zhang, Meng-Yun Wang, Jing He, Jiu-Cun Wang, Ya-Jun Yang, Li Jin, Zhi-Yu Chen, Xue-Jun Ma, Meng-Hong Sun, Kai-Qin Xia, Xiao-Nan Hong, Qing-Yi Wei, Xiao-Yan Zhou


Non-Hodgkin’s lymphoma (NHL) has been reported to be associated with autoimmune and pro-inflammatory response, and genetic polymorphisms of candidate genes involved in autoimmune and pro-inflammatory response may influence the susceptibility to NHL. To evaluate the role of such genetic variations in risk of NHL, we conducted a case-control study of 514 NHL patients and 557 cancer-free controls in a Chinese population.


We used the Taqman assay to genotype six potentially functional single nucleotide polymorphisms (SNPs) in six previously reported inflammation and immune-related genes (TNF rs1799964T>C, LTA rs1800683G>A, IL-10 rs1800872T>G, LEP rs2167270G>A, LEPR rs1327118C>G, TNFAIP8 rs1045241C>T). Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI).


We observed a significantly increased risk of NHL associated with the TNFAIP8 rs1045241C>T polymorphism (adjusted OR?=?3.03; 95% CI?=?1.68–5.45 for TT vs. CC and adjusted OR?=?2.03; 95% CI?=?1.53–2.69 for CT/TT vs. CC). The risk associated with the T allele was more evident in subgroups of 40–60 year-old, non-smokers or light-smokers (less than 25 pack-years), and subjects with normal weight or overweight. Risk for both B and T cell non-Hodgkin’s lymphoma was elevated for CT/TT genotypes (adjusted OR?=?1.95, 95% CI?=?1.41–2.70 for B cell NHL and adjusted OR?=?2.22, 95% CI?=?1.49–3.30 for T cell NHL), particularly for DLBCL (adjusted OR?=?2.01, 95%CI?=?1.41–2.85) and FL (adjusted OR?=?2.53, 95% CI?=?1.17–5.45). These risks were not observed for variant genotypes of other five SNPs compared with their common homozygous genotypes.


The polymorphism of TNFAIP8 rs1045241C>T may contribute to NHL susceptibility in a Chinese population. Further large-scale and well-designed studies are needed to confirm these results.