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PLoS By Category | Recent PLoS Articles
Neurological Disorders - Neuroscience - Ophthalmology - Physiology

Optic Nerve Head Change in Non-Arteritic Anterior Ischemic Optic Neuropathy and Its Influence on Visual Outcome
Published: Monday, May 21, 2012
Author: Jost B. Jonas et al.

by Jost B. Jonas, Sohan Singh Hayreh, Yong Tao, Konstantinos I. Papastathopoulos, Florian Rensch

Purpose

To evaluate changes in cup/disc (C/D) diameter ratios and parapapillary atrophy in patients with non-arteritic anterior ischemic optic neuropathy (NA-AION), using morphometric methods.

Methods

The clinical non-interventional study included 157 patients with unilateral or bilateral NA-AION. Optic disc photographs taken from both eyes at the end of follow-up were morphometrically examined.

Results

Follow-up was 86.3±70.3 months. Horizontal and vertical disc diameters (P?=?0.30;P?=?0.61, respectively), horizontal and vertical C/D ratios (P?=?0.47;P?=?0.19,resp.), and size of alpha zone and beta zone of parapapillary atrophy (P?=?0.27;P?=?0.32,resp.) did not differ significantly between affected eyes and contralateral normal eyes in patients with unilateral NA-AION. Similarly, horizontal and vertical disc diameters, horizontal and vertical C/D ratios, and size of alpha zone and beta zone did not vary significantly (all P>0.05) between the unaffected eyes of patients with unilateral NA-AION and the eyes of patients with bilateral NA-AION. Optic disc diameters, C/D ratios, size of alpha zone or beta zone of parapapillary atrophy were not significantly associated with final visual outcome in the eyes affected with NA-AION (all P>0.20) nor with the difference in final visual acuity between affected eyes and unaffected eyes in patients with unilateral NA-AION (all P>0.25).

Conclusions

NA-AION did not affect C/D ratios nor alpha zone and beta zone of parapapillary atrophy. Optic disc size was not related to the final visual acuity outcome in NA-AION.

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