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PLoS By Category | Recent PLoS Articles
Neurological Disorders - Ophthalmology - Physiology

Optic Nerve Head Quantification in Idiopathic Intracranial Hypertension by Spectral Domain OCT
Published: Tuesday, May 15, 2012
Author: Falko Kaufhold et al.

by Falko Kaufhold, Ella Maria Kadas, Christoph Schmidt, Hagen Kunte, Jan Hoffmann, Hanna Zimmermann, Timm Oberwahrenbrock, Lutz Harms, Konrad Polthier, Alexander U. Brandt, Friedemann Paul

Objective

To evaluate 3D spectral domain optical coherence tomography (SDOCT) volume scans as a tool for quantification of optic nerve head (ONH) volume as a potential marker for treatment effectiveness and disease progression in idiopathic intracranial hypertension (IIH).

Design and Patients

Cross-sectional pilot trial comparing 19 IIH patients and controls matched for gender, age and body mass index. Each participant underwent SDOCT. A custom segmentation algorithm was developed to quantify ONH volume (ONHV) and height (ONHH) in 3D volume scans.

Results

Whereas peripapillary retinal nerve fiber layer thickness did not show differences between controls and IIH patients, the newly developed 3D parameters ONHV and ONHH were able to discriminate between controls, treated and untreated patients. Both ONHV and ONHH measures were related to levels of intracranial pressure (ICP).

Conclusion

Our findings suggest 3D ONH measures as assessed by SDOCT as potential diagnostic and progression markers in IIH and other disorders with increased ICP. SDOCT may promise a fast and easy diagnostic alternative to repeated lumbar punctures and could therefore ease monitoring of treatment or disease progression.

  More...

 

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